Clemastine Impurity 22 CAS CATO-C4X-183722
| CAS No. | CATO-C4X-183722 |
| Molecular Formula | C21H26ClNO |
| Molecular Weight | 343.89 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Clemastine Impurity 22.
Clemastine Impurity 22 (CAS CATO-C4X-183722) is a certified pharmaceutical impurity reference standard with the molecular formula C21H26ClNO and a molecular weight of 343.89 g/mol.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Clemastine Impurity 22 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 343.89 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Clemastine Impurity 22 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H26ClNO |
| Molecular Weight | 343.89 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Clemastine Standards
- rac-Clemastine Fumarate EP Impurity B (CAS 61771-18-4)
- Clemastine Impurity 15 (CAS CATO-C4X-183715)
- Clemastine Impurity 16 (CAS CATO-C4X-183716)
- Clemastine EP Impurity B (CAS 1352549-49-5)
- Clemastine Impurity 21 (CAS CATO-C4X-183721)
- Clemastine (CAS 15686-51-8)
- Clemastine Impurity 33 (CAS CATO-C4X-183733)
- Clemastine Impurity 32 (CAS CATO-C4X-183732)
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