Clemastine Impurity 23 CAS CATO-C4X-183723
| CAS No. | CATO-C4X-183723 |
| Molecular Formula | C20H24ClNO |
| Molecular Weight | 329.86 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Clemastine Impurity 23 (CAS CATO-C4X-183723, C20H24ClNO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C20H24ClNO, Clemastine Impurity 23 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 329.86 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C20H24ClNO |
| Molecular Weight | 329.86 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Clemastine Standards
- Clemastine Impurity 32 (CAS CATO-C4X-183732)
- rac-Clemastine Fumarate EP Impurity B (CAS 61771-18-4)
- Clemastine Impurity 15 (CAS CATO-C4X-183715)
- Clemastine Impurity 16 (CAS CATO-C4X-183716)
- Clemastine EP Impurity B (CAS 1352549-49-5)
- Clemastine Impurity 21 (CAS CATO-C4X-183721)
- Clemastine Impurity 22 (CAS CATO-C4X-183722)
- Clemastine (CAS 15686-51-8)
Recommended Standards
- Cloperastine impurity 8 (CAS 132301-89-4)
- 2,3,5,6-Tetrachloro-4-(trifluoromethyl)benzoyl fluoride (CAS 117338-22-4)
- Cloperastine Impurity 1 (CAS 5630-78-4)
- 2,6-Dibromo-4-(trifluoromethyl)nicotinonitrile (CAS 1416373-32-4)
- Brexpiprazole impurity 112 (CAS CATO-C4X-1131112)
- Fingolimod EP Impurity A (CAS 1201794-93-5)
- Mirogabalin Impurity 203 (CAS CATO-C4X-2924203)
- Methyl 3-(((tert-butyldimethylsilyl)oxy)methyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-5-carboxylate (CAS 2758240-25-2)
- N-(3-Amino-4-chlorophenyl)octanamide (CAS 1020055-90-6)
- 2-(((8-Hydroxy-5-nitroquinolin-7-yl)methyl)amino)propanoic acid (CAS 84677-20-3)
- 4-(Azetidin-3-yl)-2,6-dichloropyridine (CAS 1260869-26-8)
- 7,8-Dimethoxy-1,3-dimethylfuro[3,4-c]quinolin-4(5H)-one (CAS 89193-38-4)
- 2-(4-Chloro-1H-pyrazol-1-yl)propan-1-ol (CAS 1427716-20-8)
- Galanin-Like Peptide (rat) trifluoroacetate salt (CAS 245114-97-0)
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