Nicorandil Impurity 51 HCl CAS CATO-C4X-190751
| CAS No. | CATO-C4X-190751 |
| Molecular Formula | C16H18N4O3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Nicorandil Impurity 51 HCl (CAS CATO-C4X-190751, C16H18N4O3HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Nicorandil Impurity 51 HCl (C16H18N4O3HCl) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 350.80 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C16H18N4O3 HCl |
| Molecular Weight | 350.80 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Nicorandil Standards
- Nicorandil N-Oxide (CAS 107833-98-7)
- Nicorandil-d4 (CAS 1132681-23-2)
- Nicorandil Impurity 7 (CAS 113743-17-2)
- Nicorandil Impurity 5 (CAS 1157-74-0)
- Nicorandil Impurity 47 (CAS 13362-26-0)
- Nicorandil Impurity 26 (CAS 14906-63-9)
- Nicorandil Impurity 24 (CAS 149415-43-0)
- Nicorandil Impurity 43 (CAS 1570-45-2)
Recommended Standards
- Ixazomib Impurity 26 (CAS CATO-C4X-126726)
- Acetazolamide EP Impurity A (CAS 60320-32-3)
- Palbociclib impurity 131 (CAS CATO-C4X-1125131)
- 2-Fluoro-1-(2,2,2-trifluoroethyl)-4-(trifluoromethyl)benzene (CAS 1099597-72-4)
- 4-(2-Aminoethyl)tetrahydropyran (CAS 65412-03-5)
- Terbutaline Impurity 37 (CAS 28917-43-3)
- 5,5-Difluoro-2-Azabicyclo[2.2.1]Heptane (CAS 1932605-16-7)
- N-((2,6-difluorophenyl)carbamoyl)-4-methylbenzenesulfonamide (CAS 866151-79-3)
- 3-Amino-N-(5-chloro-2-methylphenyl)-6-(pyridin-4-yl)thieno[2,3-b]pyridine-2-carboxamide (CAS 625370-62-9)
- Tirzepatide Impurity 48 (CAS CATO-C4X-324048)
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