Nicorandil Impurity 24 CAS 149415-43-0
| CAS No. | 149415-43-0 |
| Molecular Formula | C10H14N2O3 |
| Molecular Weight | 210.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Nicorandil Impurity 24 (CAS 149415-43-0, C10H14N2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Nicorandil Impurity 24 (C10H14N2O3) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C10H14N2O3 |
| Molecular Weight | 210.23 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Nitrogen Atoms | 2 |
Related Nicorandil Standards
- Nicorandil Impurity 20 (CAS 70892-82-9)
- Nicorandil (CAS 65141-46-0)
- Nicorandil EP Impurity A (CAS 65141-47-1)
- Nicorandil Impurity 30 (CAS CATO-C4X-190730)
- Nicorandil Impurity 48 (CAS CATO-C4X-190748)
- Nicorandil Impurity 52 (CAS CATO-C4X-190752)
- Nicorandil Impurity 19 (CAS CATO-C4X-190719)
- Nicorandil Impurity 12 (CAS 83440-03-3)
Recommended Standards
- Nikethamide impurity 21 (CAS 1790752-17-8)
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- Carbidopa Impurity 35 (CAS 2104012-68-0)
- Cefradine Impurity 17 (CAS CATO-C4X-121517)
- Flupentixol Impurity 34 (CAS 30909-52-5)
- Elacestrant Impurity 12 (CAS 722533-24-6)
- 2-Amino-2,5-dimethylhexanoic acid (CAS 21160-88-3)
- (2-((2-Fluorobenzyl)thio)-4,5-dihydro-1H-imidazol-1-yl)(4-fluorophenyl)methanone (CAS 851806-92-3)
- N2-(Phenylmethyl)-2,5-pyridinediamine (CAS 21630-48-8)
- (2R,3S,4R)-2-(Aminomethyl)-5-methoxytetrahydrofuran-3,4-diol (CAS 474105-03-8)
- 2-(2-((4-Chlorophenyl)sulfonyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)acetic acid (CAS 378227-98-6)
- Methyl 6-bromo-5-chloropyrazine-2-carboxylate (CAS 1017603-87-0)
- 1-His-N-a-ethylidene Semaglutide (CAS CATO-C4X-2226252)
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