Nicorandil Impurity 47 CAS 13362-26-0
| CAS No. | 13362-26-0 |
| Molecular Formula | C8H10N2O2 |
| Molecular Weight | 166.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Nicorandil Impurity 47 (C8H10N2O2) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Nicorandil Impurity 47 (CAS 13362-26-0, C8H10N2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Nicorandil Impurity 47 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H10N2O2 |
| Molecular Weight | 166.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1960 |
| Nitrogen Atoms | 2 |
Related Nicorandil Standards
- Nicorandil Impurity N1 (CAS 46053-56-9)
- Nicorandil Impurity 17 (CAS 6265-74-3)
- Nicorandil EP Impurity B (CAS 6265-73-2)
- Nicorandil Impurity 57 (CAS 342018-76-2)
- Nicorandil Impurity 26 (CAS 14906-63-9)
- Nicorandil Impurity 43 (CAS 1570-45-2)
- Nicorandil Impurity 13 (CAS 896133-95-2)
- Nicorandil Impurity 28 (CAS CATO-C4X-190728)
Recommended Standards
- Bumetanide Impurity 43 (CAS 6633-36-9)
- Thiamine /Vitamin B1 Impurity 18 (CAS 1886-34-6)
- Pyridostigmine Bromide EP Impurity A (CAS 51581-32-9)
- Acipimox Impurity 14 (CAS 98006-89-4)
- Cinacalcet Impurity 50 (CAS 941-98-0)
- Argatroban Impurity 142 (CAS CATO-C4X-1007142)
- Pregabalin Impurity 21 (CAS 181289-11-2)
- 1-(Hexadecyloxy)-4-methylbenzene (CAS 57792-42-4)
- N-(Pentafluoropropionyl)imidazole (CAS 71735-32-5)
- 3-Chloro-n-(2-fluorophenyl)propanamide (CAS 349097-66-1)
- 2,4-Dibromo-3,5-difluorobenzenesulfonamide (CAS 1208076-82-7)
- Phenyl n-(piperidin-4-yl)carbamate hydrochloride (CAS 1251924-51-2)
- 3-phenyl-8-azabicyclo[3.2.1]oct-2-ene hydrochloride (CAS 36769-06-9)
- Semaglutide Impurity 5 (CAS 23406-82-8)
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