Flumetasone Impurity 18 CAS CATO-C4X-191018
| CAS No. | CATO-C4X-191018 |
| Molecular Formula | C21H25FO6 |
| Molecular Weight | 392.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Flumetasone Impurity 18 (CAS CATO-C4X-191018, C21H25FO6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Flumetasone Impurity 18 (C21H25FO6) is characterized by a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Flumetasone Impurity 18 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H25FO6 |
| Molecular Weight | 392.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
Related Flumetasone Standards
- Flumetasone Impurity 15 (CAS CATO-C4X-191015)
- Flumetasone Impurity 10 (CAS 382631-11-0)
- Flumetasone Impurity 19 (CAS CATO-C4X-191019)
- Flumetasone Impurity 17 (CAS CATO-C4X-191017)
- Flumetasone Impurity 16 (CAS CATO-C4X-191016)
- Flumetasone Impurity 9 (CAS 2541-37-9)
- Flumetasone Impurity 14 (CAS 3873-19-6)
- Flumetasone Impurity 7 (CAS 61633-73-6)
Recommended Standards
- Triamcinolone Acetonide Impurity 43 (CAS CATO-C4X-132643)
- 2-((6-(4-(1H-Pyrazol-1-yl)phenyl)pyridazin-3-yl)thio)-N-(5-methylisoxazol-3-yl)acetamide (CAS 1004439-73-9)
- Tadalafil-d3 (CAS 960226-55-5)
- (E)-4-Amino-5-fluoro-3-(5-(4-methylpiperazin-1-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)quinolin-2(3H)-one (CAS 1027263-12-2)
- Posaconazole Impurity 35 (CAS 1370190-85-4)
- Omeprazole Impurity 60 (CAS 150054-47-0)
- Bisoprolol EP Impurity G (CAS 1215342-36-1)
- (2E)-2-[(E)-Benzoyl]-3-[4-(2,6-difluorobenzoyl)-1-methyl-1H-pyrrol-2-yl]prop-2-enenitrile (CAS 338978-26-0)
- 6-(Isopropylamino)-4-methylnicotinic acid (CAS 1355215-58-5)
- 1-Cyclopropoxy-4-isopropoxy-2-isopropylbenzene (CAS 1243352-11-5)
- 3-Chloro-5-iodo-1H-indazole (CAS 885519-14-2)
- 1-(1-(2-Methoxyethyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-((5-methyl-1,3,4-thiadiazol-2-yl)thio)ethan-1-one (CAS 690642-71-8)
- 6-bromo-1',1'-difluoro-spiro[2,3-dihydroisoquinoline-4,2'-cyclopropane]-1-one (CAS 2771025-18-2)
- Neuroendocrine Regulatory Peptide-1 (human) (H-6622.1000) (CAS 954420-50-9)
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