Tolvaptan Impurity 48 CAS CATO-C4X-195548
| CAS No. | CATO-C4X-195548 |
| Molecular Formula | C26H27N2O6P |
| Molecular Weight | 494.48 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Tolvaptan Impurity 48 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Tolvaptan Impurity 48 (CAS CATO-C4X-195548, C26H27N2O6P) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Tolvaptan Impurity 48 (C26H27N2O6P) contains a steroid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 14.5, corresponding to approximately 14 ring(s) or double-bond equivalent(s). With a molecular weight of 494.48 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C26H27N2O6P |
| Molecular Weight | 494.48 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 2 |
Related Tolvaptan Standards
- Tolvaptan impurity 112 (CAS CATO-C4X-1955112)
- Tolvaptan Impurity 25 (CAS 2921676-63-1)
- Tolvaptan Impurity 7 (CAS 1346599-75-4)
- Tolvaptan Impurity 15 (CAS 1346599-56-1)
- Tolvaptan Impurity 105 (CAS 942619-93-4)
- Tolvaptan Impurity 75 (CAS CATO-C4X-195575)
- Tolvaptan Impurity 62 (CAS 2657689-30-8)
- Tolvaptan Impurity 51 (CAS CATO-C4X-195551)
Recommended Standards
- Ethyl 7-methyl-2-(4-nitrobenzylidene)-5-(3-nitrophenyl)-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate (CAS 300377-52-0)
- Elobixibat Impurity 32 (CAS CATO-C4X-283832)
- 8-(Acetyl(4'-Fluoro(1,1'-Biphenyl)-4-ylAmino)-2'-Deoxy-Guanosine (CAS 67764-18-5)
- Hydramethylnon (CAS 67485-29-4)
- Benzylpenicillin Impurity 54 (CAS 90962-63-3)
- Edoxaban Impurity N37 (CAS 365997-34-8)
- Choline impurity 1 (CAS 92442-84-7)
- 4-(1-Methyl-5-imidazolyl)phenol (CAS 74730-75-9)
- 1-(4-Bromopyridin-3-yl)cyclopropane-1-carbonitrile (CAS 1780805-39-1)
- Methyl 4-(4-Boc-1-piperazinyl)-2-chlorobenzoate (CAS 1346597-59-8)
- Pyridaphenthion (CAS 119-12-0)
- 1-Methyl-3-phenyl-1,4,6,7-tetrahydroimidazo[2,1-c][1,2,4]triazine (CAS 62638-35-1)
- 6-Bromo-N-hydroxyisoquinoline-1-carboximidamide (CAS 2089315-70-6)
- Semaglutide impurity 227 (CAS CATO-C4X-2226227)
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