Tolvaptan Impurity 25 CAS 2921676-63-1
| CAS No. | 2921676-63-1 |
| Molecular Formula | C26H25BrN2O3 |
| Molecular Weight | 493.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Tolvaptan Impurity 25.
CATO supplies Tolvaptan Impurity 25 (CAS 2921676-63-1), a pharmacopoeial impurity reference standard (molecular formula C26H25BrN2O3, MW 493.39 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C26H25BrN2O3, Tolvaptan Impurity 25 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 493.39 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C26H25BrN2O3 |
| Molecular Weight | 493.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2004 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Tolvaptan Standards
- Tolvaptan impurity 112 (CAS CATO-C4X-1955112)
- Tolvaptan Impurity 48 (CAS CATO-C4X-195548)
- Tolvaptan Impurity 7 (CAS 1346599-75-4)
- Tolvaptan Impurity 15 (CAS 1346599-56-1)
- Tolvaptan Impurity 105 (CAS 942619-93-4)
- Tolvaptan Impurity 75 (CAS CATO-C4X-195575)
- Tolvaptan Impurity 51 (CAS CATO-C4X-195551)
- Tolvaptan Impurity 96 (CAS 1587638-01-4)
Recommended Standards
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- Nonyl Undecyl Phthalate (CAS 65185-89-9)
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- 3,3'-Dimethyl-[1,1'-biphenyl]-4,4'-diamine compound with o-cresol (1:1) (CAS 121476-13-9)
- ((2R,3R,4S,5R,6S)-3,4,5-tris(benzyloxy)-6-(p-tolylthio)tetrahydro-2H-pyran-2-yl)methanol (CAS 479252-05-6)
- 4,4-Di(hydroxymethyl)-1-methyl-1-cyclohexene (CAS 15827-42-6)
- Semaglutide impurity 97 (CAS CATO-C4X-222697)
Why CATO?
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