Nebivolol Impurity 41 CAS CATO-C4X-196841
| CAS No. | CATO-C4X-196841 |
| Molecular Formula | C24H29F2NO4 |
| Molecular Weight | 433.49 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Nebivolol Impurity 41 (CAS CATO-C4X-196841, C24H29F2NO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Nebivolol Impurity 41 (C24H29F2NO4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Nebivolol Impurity 41 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H29F2NO4 |
| Molecular Weight | 433.49 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Nebivolol Standards
- Nebivolol Impurity 1 (Mixture of Diastereomers) (CAS CATO-C4X-19681)
- Nebivolol Impurity 39 (CAS CATO-C4X-196839)
- Nebivolol-D6 N-Nitroso (CAS CATO-C4X-1968102)
- rac Nebivolol-d8 (CAS 1219166-00-3)
- Nebivolol-D6 (CAS 99200-09-6 (unlabeled))
- rac Nebivolol-d4 (CAS 1219407-55-2)
- Nebivolol Impurity 105 (CAS 1345202-53-0)
- Nebivolol Impurity 50 (CAS CATO-C4X-196850)
Recommended Standards
- Mycophenolate Mofetil EP Impurity C (Z-isomer) (CAS 2286278-51-9)
- Mycophenolate Mofetil (CAS 115007-34-6)
- Mycophenolate Mofetil (CAS 128794-94-5)
- Z-Ala-Pro-Leu-OH (CAS 108074-19-7)
- Vonoprazan Impurity 223 (CAS 13069-04-0)
- Indacaterol Impurity 23(and enantiomer) HCl (CAS 62910-96-7)
- Efinaconazole impurity 44 (CAS CATO-C4X-124344)
- (2R,3S)-4-(tert-Butoxycarbonyl)-2-methylmorpholine-3-carboxylic acid (CAS 1807938-50-6)
- 1-(2-Furylmethyl)-4-hydroxy-6-methylpyridin-2(1H)-one (CAS 638139-12-5)
- Mitoxantrone Impurity 19 (CAS CATO-C4X-103419)
- [1,1':3',1''-Terphenyl]-5'-ol (CAS 28023-86-1)
- Methyl (tert-butoxycarbonyl)-D-phenylalanyl-L-leucinate (CAS 129279-71-6)
- 3-(2-Ethoxyphenoxy)azetidine (CAS 1220028-15-8)
- Heme iron polypeptide(Hematin) (CAS 14875-96-8)
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