Nebivolol Impurity 77 CAS CATO-C4X-196877
| CAS No. | CATO-C4X-196877 |
| Molecular Formula | C29H31F2NO4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Nebivolol Impurity 77.
As a process- or degradation-related impurity, Nebivolol Impurity 77 (CAS CATO-C4X-196877, C29H31F2NO4HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C29H31F2NO4HCl, Nebivolol Impurity 77 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 532.02 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Nebivolol Impurity 77 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C29H31F2NO4 HCl |
| Molecular Weight | 532.02 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Nebivolol Standards
- Nebivolol Impurity 66 (CAS 1017878-67-9)
- Nebivolol Impurity 15 (CAS 1029684-20-5)
- Nebivolol Impurity 20 (CAS 105300-40-1)
- Nebivolol Impurity 28 (CAS 112068-01-6)
- D-Nebivolol (SR,RR) (CAS 118457-15-1)
- L-Nebivolol (RS,SS) (CAS 118457-16-2)
- Nebivolol Hydrochloride EP Impurity B (CAS 119365-23-0)
- Nebivolol Impurity 32（SS,RS）or（SR,SS） (CAS 119365-25-2)
Recommended Standards
- Rosuvastatin Impurity 210 (CAS CATO-C4X-1169210)
- Florfenicol Impurity 16 (CAS CATO-C4X-207516)
- Melatonin Impurity 25 (CAS 573983-93-4)
- 4-chloro-2-(chloromethyl)-6-ethylpyrimidine (CAS 77457-72-8)
- 7-Chloro-2-(methylsulfinyl)benzo[d]thiazole (CAS 1163123-64-5)
- 9-((4-Chlorobutyl)thio)acridine (CAS 827303-12-8)
- 3-Amino-3-(1-methyl-1H-imidazol-2-yl)propanamide (CAS 771521-47-2)
- Thiazol-2-yl(2,4,5-trifluorophenyl)methanone (CAS 1443304-82-2)
- Diphenyl4-tert-butylphenylsulfoniumnonafluorobutanesulfonate (CAS 258872-05-8)
- Neuropeptide S (human) (CAS 412938-67-1)
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