Nebivolol Impurity 8 CAS CATO-C4X-19688
| CAS No. | CATO-C4X-19688 |
| Molecular Formula | C12H16FNO2 |
| Molecular Weight | 225.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Nebivolol Impurity 8 (CAS CATO-C4X-19688), a pharmacopoeial impurity reference standard (molecular formula C12H16FNO2, MW 225.26 g/mol) used for the identification and quantification of trace impurities in APIs.
Nebivolol Impurity 8 (C12H16FNO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Nebivolol Impurity 8 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H16FNO2 |
| Molecular Weight | 225.26 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Nebivolol Standards
- Nebivolol Impurity 10 (CAS CATO-C4X-196810)
- Nebivolol Impurity 11 (CAS CATO-C4X-196811)
- Nebivolol Impurity 9 (CAS CATO-C4X-19689)
- Nebivolol Impurity 60 (CAS CATO-C4X-196860)
- Nebivolol Impurity 23 (CAS CATO-C4X-196823)
- Nebivolol Impurity 24 (CAS CATO-C4X-196824)
- Nebivolol Impurity 27 (CAS CATO-C4X-196827)
- Nebivolol Impurity 68 (CAS CATO-C4X-196868)
Recommended Standards
- Acetazolamide-d3 (CAS 1189904-01-5)
- Ethyl Sulbactam Impurity A (CAS CATO-C4X-175635)
- 4-(Cyclopropylamino)-2-(methylthio)pyrimidine-5-carboxylic acid (CAS 1015856-32-2)
- Flurbiprofen impurity 121 (CAS 74648-00-3)
- Olprinone Impurity 25 (CAS 1463413-21-9（free base）)
- Abacavir Impurity N2 (CAS 783292-37-5)
- Sofosbuvir Impurity 52 (CAS CATO-C4X-105252)
- (5-Methoxy-1H-indol-2-yl)methanamine hydrochloride (CAS 130445-27-1)
- (3-tert-Butoxyphenyl)boronic acid (CAS 312931-06-9)
- 4-Amino-2-methyl-5-nitrobenzoic acid (CAS 408507-93-7)
- 3-Isopropoxy-1-methyl-1H-pyrazole-5-carboxylic acid (CAS 1784566-90-0)
- Terpenylic acid (CAS 26754-48-3)
- Bis(4-(1H-imidazol-1-yl)phenyl)methanone (CAS 343375-12-2)
- Acetyl decapeptide-3 (CAS 935288-50-9)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com