Nebivolol Impurity 27 CAS CATO-C4X-196827
| CAS No. | CATO-C4X-196827 |
| Molecular Formula | C11H10ClFO2 |
| Molecular Weight | 228.65 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Nebivolol Impurity 27 (CAS CATO-C4X-196827), a pharmacopoeial impurity reference standard (molecular formula C11H10ClFO2, MW 228.65 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Nebivolol Impurity 27 (C11H10ClFO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
CATO manufactures Nebivolol Impurity 27 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C11H10ClFO2 |
| Molecular Weight | 228.65 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
Related Nebivolol Standards
- Nebivolol Impurity 23 (CAS CATO-C4X-196823)
- Nebivolol Impurity 24 (CAS CATO-C4X-196824)
- Nebivolol Impurity 68 (CAS CATO-C4X-196868)
- Nebivolol Impurity 71 (CAS CATO-C4X-196871)
- Nebivolol Impurity 66 (CAS 1017878-67-9)
- Nebivolol Impurity 72 (CAS CATO-C4X-196872)
- Nebivolol Impurity 73 (CAS CATO-C4X-196873)
- Nebivolol Impurity 10 (CAS CATO-C4X-196810)
Recommended Standards
- Phosphorochloridic acid, dibutyl ester (CAS 819-43-2)
- 3-(5-chlorothiophen-2-yl)-1H-pyrazole-4-carboxylic acid (CAS 1155045-53-6)
- Methyl (2Z)-2-(chloromethyl)-3-(4-fluorophenyl)prop-2-enoate (CAS 847653-89-8)
- 3-(5-Chloro-thiophen-2-yl)-1H-pyrazole-5-carboxylic acid (CAS 1188375-25-8)
- Pomalidomide Impurity 30 (CAS CATO-C4X-135430)
- Lenvatinib Impurity 85 (CAS CATO-C4X-114085)
- Ulipristal Impurity 19 (CAS CATO-C4X-191519)
- 1-(2-Methyl-3-(trifluoromethyl)phenyl)ethanol (CAS 1488356-50-8)
- N-((1,1-Dioxidotetrahydrothiophen-3-yl)methyl)benzo[d][1,3]dioxole-5-carboxamide (CAS 1223198-91-1)
- 2-Fluorosuccinic acid (CAS 687-50-3)
- 1-(3,4-Dimethylbenzyl)piperazine (CAS 212393-09-4)
- Prilocaine impurity 53 (CAS CATO-C4X-193453)
- 3-Cycloheptyl-1-methyl-1h-pyrazol-5-amine (CAS 118430-75-4)
- Peptide T (CAS 106362-32-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com