Nebivolol Impurity 95 CAS CATO-C4X-196895
| CAS No. | CATO-C4X-196895 |
| Molecular Formula | C41H46ClF2N3O8 |
| Molecular Weight | 782.27 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Nebivolol Impurity 95 (C41H46ClF2N3O8) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Nebivolol Impurity 95 (CAS CATO-C4X-196895) is a certified pharmaceutical impurity reference standard with the molecular formula C41H46ClF2N3O8 and a molecular weight of 782.27 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C41H46ClF2N3O8 |
| Molecular Weight | 782.27 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 19.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Nebivolol Standards
- Nebivolol Impurity 98 (CAS CATO-C4X-196898)
- Nebivolol Impurity 93 (CAS CATO-C4X-196893)
- Nebivolol Impurity 94 (CAS CATO-C4X-196894)
- Nebivolol Impurity 90 (CAS CATO-C4X-196890)
- Nebivolol Impurity 92 (CAS CATO-C4X-196892)
- Nebivolol Impurity 101 (CAS CATO-C4X-1968101)
- Nebivolol Impurity 96 (CAS CATO-C4X-196896)
- Nebivolol Impurity 100 (CAS CATO-C4X-1968100)
Recommended Standards
- DOBAQ (CAS 1360461-69-3)
- 18:2 (Cis) PC (DLPC)（contains~3.0% H2O） (CAS 998-06-1)
- 1,2-Bis(dipentafluorophenylphosphino)ethane 76858-94-1 1,2-BIS(BIS(PERFLUOROPHENYL)PHOSPHINO)ETHANE;1,2-BIS(DIPENTAFLUOROPHENYLPHOSPHINO)ETHANE;1,2-BIS[BIS(PENTAFLUOROPHENYL)PHOSPHINO]ETHANE;1,2-ETHANEDIYLBIS[BIS(PENTAFLUOROPHENYL)PHOSPHINE];BIS(DIPENTAFLUOROPHENYLPHOSPHINE)ETHANE;DFPPE;ETHANE-1,2-DIYLBIS[BIS(PENTAFLUOROPHENYL)PHOSPHANE] SC11244 (CAS 76858-94-1)
- 2,3-Bis(((9Z,12Z)-octadeca-9,12-dienoyl)oxy)propyl (2-(trimethylammonio)ethyl) phosphate (CAS 6542-05-8)
- Nortriptyline EP Impurity J (CAS 4317-14-0)
- Hydrocortisone EP Impurity G (CAS 14760-49-7)
- Terbutaline Impurity 62 (CAS CATO-C4X-118362)
- 6-(Trifluoromethyl)-1,2,3,4-tetrahydro-1,5-naphthyridine hydrochloride (CAS 1356110-30-9)
- 686353-29-7 (CAS 686353-29-7)
- 3-Bromo-5,6,7,8-tetrahydroquinoline-5-carboxylicacid (CAS 1256805-14-7)
- Lusutrombopag Impurity 17 (CAS CATO-C4X-208417)
- 2-Amino-N-butyl-N,2-dimethylpropanamidehydrochloride (CAS 1220034-85-4)
- 3-Amino-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one (CAS 103421-61-0)
- Peptide 431 (CAS CATO-CPTD788431)
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