Nebivolol Impurity 99 CAS CATO-C4X-196899
| CAS No. | CATO-C4X-196899 |
| Molecular Formula | C28H29F2NO6S |
| Molecular Weight | 545.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Nebivolol Impurity 99 (CAS CATO-C4X-196899) is a certified pharmaceutical impurity reference standard with the molecular formula C28H29F2NO6S and a molecular weight of 545.59 g/mol.
Structurally, Nebivolol Impurity 99 (C28H29F2NO6S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 14.0, corresponding to approximately 14 ring(s) or double-bond equivalent(s). With a molecular weight of 545.59 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C28H29F2NO6S |
| Molecular Weight | 545.59 g/mol |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Nebivolol Standards
- Nebivolol Impurity 97 (CAS CATO-C4X-196897)
- Nebivolol Impurity 91 (CAS CATO-C4X-196891)
- Nebivolol Impurity 100 (CAS CATO-C4X-1968100)
- Nebivolol Impurity 89 (CAS CATO-C4X-196889)
- Nebivolol Impurity N1 (CAS 929706-85-4)
- Nebivolol Impurity 35 (CAS 1199945-26-0)
- Nebivolol-D6 N-Nitroso (CAS CATO-C4X-1968102)
- Nebivolol Impurity 39 (CAS CATO-C4X-196839)
Recommended Standards
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- 2-((2S,3R,4R,5S,6R)-4-(allyloxy)-6-((benzyloxy)methyl)-5-hydroxy-2-(4-methoxyphenoxy)tetrahydro-2H-pyran-3-yl)isoindoline-1,3-dione (CAS 1820583-64-9)
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- Flomoxef Impurity 5 (CAS 134237-56-2)
- 5-Fluoro-2'-(hydrazinecarbonyl)-[1,1'-biphenyl]-2-carboxylic acid (CAS 732-95-6)
- 2-(3-(1H-pyrrol-1-yl)phenyl)-4-methylthiazole-5-carbohydrazide (CAS 262589-42-4)
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- Ethyl 3-ethylpentanoate (CAS 80246-72-6)
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- Ethanesulfonic acid, 2-[[(2S)-2-amino-3-(1H-indol-3-yl)-1-oxopropyl]amino]- (CAS 1460283-82-2)
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