Bumetanide Impurity 133 CAS CATO-C4X-1986133
| CAS No. | CATO-C4X-1986133 |
| Molecular Formula | C7H5ClN2O6S |
| Molecular Weight | 280.64 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Bumetanide Impurity 133.
As a process- or degradation-related impurity, Bumetanide Impurity 133 (CAS CATO-C4X-1986133, C7H5ClN2O6S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C7H5ClN2O6S, Bumetanide Impurity 133 contains a carbohydrate-derived structure, an amide group, a sulfone group, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 280.64 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H5ClN2O6S |
| Molecular Weight | 280.64 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Bumetanide Standards
- Bumetanide Impurity 45 (CAS 61658-42-2)
- Bumetanide Impurity 48 (CAS CATO-C4X-198648)
- Bumetanide Impurity 5 (CAS 22892-96-2)
- Bumetanide Impurity 80 (CAS CATO-C4X-198680)
- Bumetanide Impurity 73 (CAS CATO-C4X-198673)
- Bumetanide Impurity 7 (CAS 130262-91-8)
- Bumetanide Impurity 40 (CAS 688047-82-7)
- Bumetanide Impurity 78 (CAS CATO-C4X-198678)
Recommended Standards
- 7-Chloro-3-(methoxycarbonyl)-4-oxo-1,4-dihydroquinoline-2-carboxylic acid (CAS 170143-39-2)
- 1-((2R,3S,4R,5R)-3-chloro-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione (CAS 1673560-41-2)
- 1-(3-Chloro-5-(pentafluoro-λ6-sulfanyl)phenyl)ethan-1-one (CAS 1180486-96-7)
- 2-Chloro-N-(4,5,6-trifluoro-1,3-benzothiazol-2-yl)acetamide (CAS 379255-48-8)
- Biperiden EP Impurity D (CAS 475563-21-4)
- Mirabegron Impurity 110 (CAS CATO-C4X-1032110)
- Norepinephrine impurity 90 HCl (CAS 2947-04-8(free base))
- 4-((2,2,2-Trifluoroethyl)thio)benzoic acid (CAS 954562-94-8)
- (S)-5'-Bromo-2',3'-dihydrospiro[imidazolidine-4,1'-indene]-2,5-dione (CAS 1889290-53-2)
- 5-Bromo-2-chloro-3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine (CAS 1299607-46-7)
- Methyl 3,6-dibromopyridine-2-acetate (CAS 1804936-27-3)
- Ethyl 2-(3-(aminomethyl)oxetan-3-yl)acetate (CAS 1207175-75-4)
- N-cyclopropyl-4-[(cyclopropylamino)methyl]benzamide (CAS 1000932-00-2)
- Semaglutide impurity 289 (CAS CATO-C4X-2226289)
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