Crisaborole Impurity 143 CAS CATO-C4X-2021143
| CAS No. | CATO-C4X-2021143 |
| Molecular Formula | C15H10BrNO3 |
| Molecular Weight | 332.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Crisaborole Impurity 143 (CAS CATO-C4X-2021143) is a certified pharmaceutical impurity reference standard with the molecular formula C15H10BrNO3 and a molecular weight of 332.15 g/mol.
Based on its molecular formula C15H10BrNO3, Crisaborole Impurity 143 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 332.15 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C15H10BrNO3 |
| Molecular Weight | 332.15 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Crisaborole Standards
- Crisaborole lmpurity 84 (CAS CATO-C4X-202184)
- Crisaborole Impurity 12 (CAS CATO-C4X-202112)
- Crisaborole impurity 158 (CAS CATO-C4X-2021158)
- Crisaborole impurity 124 (CAS CATO-C4X-2021124)
- Crisaborole impurity 127 (CAS CATO-C4X-2021127)
- Crisaborole Impurity 58 (CAS CATO-C4X-202158)
- Crisaborole Impurity 57 (CAS CATO-C4X-202157)
- Crisaborole Impurity 19 (CAS CATO-C4X-202119)
Recommended Standards
- Bromfenac Impurity 56 (CAS CATO-C4X-200256)
- 3-Ethyl-6-iodo-2-thioxo-2,3-dihydroquinazolin-4(1H)-one (CAS 111631-31-3)
- Bromfenac Impurity 55 (CAS CATO-C4X-200255)
- 3-Ethyl-5-(3-iodophenoxy)-1,2,4-thiadiazole (CAS 1493595-03-1)
- Atomoxetine Impurity 32 (CAS CATO-C4X-155032)
- Thiamine /Vitamin B1 Impurity 18 (CAS 1886-34-6)
- Alogliptin Impurity 60 (CAS 2514763-78-9)
- 2-Ethyl-5-methyl-1h-imidazol-3-ium tetraphenylborate (CAS 53831-70-2)
- 8-(Iodomethyl)-1,4-dioxaspiro[4.5]Decane (CAS 625114-56-9)
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- 2-Cyclohexyl-N-cyclopropylcyclohexan-1-amine (CAS 1152956-96-1)
- 4-Cyano-1-(pyridin-4-ylmethyl)piperidine-4-carboxylic acid (CAS 1889892-74-3)
- 2-(P-tolyl)cyclopropane-1-carbohydrazide (CAS 438219-20-6)
- D-allo-Thr7-Semaglutide (CAS CATO-C4X-2226242)
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