Crisaborole Impurity 58 CAS CATO-C4X-202158
| CAS No. | CATO-C4X-202158 |
| Molecular Formula | C14H11BrO4 |
| Molecular Weight | 323.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Crisaborole Impurity 58 (CAS CATO-C4X-202158) is a certified pharmaceutical impurity reference standard with the molecular formula C14H11BrO4 and a molecular weight of 323.14 g/mol.
The molecular framework of Crisaborole Impurity 58 (C14H11BrO4) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C14H11BrO4 |
| Molecular Weight | 323.14 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
Related Crisaborole Standards
- Crisaborole impurity 127 (CAS CATO-C4X-2021127)
- Crisaborole Impurity 57 (CAS CATO-C4X-202157)
- Crisaborole Impurity 19 (CAS CATO-C4X-202119)
- Crisaborole Impurity 55 (CAS CATO-C4X-202155)
- Crisaborole impurity 121 (CAS CATO-C4X-2021121)
- Crisaborole impurity 118 (CAS CATO-C4X-2021118)
- Crisaborole lmpurity 95 (CAS CATO-C4X-202195)
- Crisaborole lmpurity 73 (CAS 2473730-47-9)
Recommended Standards
- N-{3-[(2-Bromoacetyl)amino]phenyl}-2-furamide (CAS 885983-65-3)
- 2,5-Dichloro-4-(3-methyl-5-oxo-2,5-dihydro-1H-pyrazol-1-yl)benzenesulfonic acid (CAS 108-46-9)
- Diethyl (3,4-dichlorophenyl)(fluoro)malonate (CAS 29246-13-7)
- 2,5-Dichloro-4-(5-hydroxy-3-methyl-1H-pyrazol-1-yl)benzenesulfonic acid (CAS 108469-42-7)
- Avanafil Impurity 33 (CAS CATO-C4X-111833)
- Perphenazine Impurity C27 (CAS 2765-59-5)
- Fluocinolone Acetonide Impurity 15 (CAS 1181-32-4)
- [1-(3-methylphenyl)cyclopentyl]methanamine (CAS 1098349-30-4)
- 4-(2-Methoxyethoxy)benzonitrile (CAS 80407-66-5)
- 4-Bromo-3-methylphenol (CAS 14472-14-1)
- 2-(Bromomethyl)-1,3-difluoro-4-methoxybenzene (CAS 886498-55-1)
- 3-Bromoselenophene (CAS 25109-24-4)
- ((2R,3S,4R,5R)-5-(2-Formamidoacetimidamido)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate (CAS 6157-85-3)
- Tirzepatide Impurity 9 (CAS CATO-C4X-32409)
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