Crisaborole impurity 158 CAS CATO-C4X-2021158
| CAS No. | CATO-C4X-2021158 |
| Molecular Formula | C16H15BrO3 |
| Molecular Weight | 335.19 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 335.19 g/mol gives Crisaborole impurity 158 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Crisaborole impurity 158 (CAS CATO-C4X-2021158), a pharmacopoeial impurity reference standard (molecular formula C16H15BrO3, MW 335.19 g/mol) used for the identification and quantification of trace impurities in APIs.
Crisaborole impurity 158 (C16H15BrO3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, a polycyclic aromatic system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H15BrO3 |
| Molecular Weight | 335.19 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
Related Crisaborole Standards
- Crisaborole impurity 124 (CAS CATO-C4X-2021124)
- Crisaborole lmpurity 84 (CAS CATO-C4X-202184)
- Crisaborole Impurity 143 (CAS CATO-C4X-2021143)
- Crisaborole Impurity 12 (CAS CATO-C4X-202112)
- Crisaborole impurity 128 (CAS CATO-C4X-2021128)
- Crisaborole lmpurity 100 (CAS CATO-C4X-2021100)
- Crisaborole lmpurity 101 (CAS CATO-C4X-2021101)
- Crisaborole impurity 105 (CAS CATO-C4X-2021105)
Recommended Standards
- Telmisartan Impurity 92 (CAS CATO-C4X-135992)
- 2-(((4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)amino)methylene)malononitrile (CAS 1022735-10-9)
- N4-(3,4-Dichlorophenyl)-7-methoxyquinazoline-4,6-diamine (Dacomitinib Impurity) (CAS 2803451-99-0)
- Ethyl 2-(benzylamino)-5-bromonicotinate (CAS 1186404-92-1)
- Cefotiam Impurity 23 (CAS CATO-C4X-120423)
- Sulpiride EP Impurity B (CAS 33045-52-2)
- Nebivolol Impurity 45 (CAS 129050-26-6)
- 1-(2-Chloro-6-(chloromethyl)pyridin-4-yl)ethan-1-one (CAS 1393570-32-5)
- 1-Bromo-3-(bromomethyl)-5-chlorobenzene (CAS 762292-63-7)
- Imibenconazole (CAS 86598-92-7)
- Liraglutide (CAS 204656-20-2)
- 2-Chloro-N-methyl-N-((1-methylpiperidin-2-yl)methyl)acetamide (CAS 1353951-54-8)
- (4S,4'S)-2,2'-(ethane-1,1-diyl)bis(4-isopropyl-4,5-dihydrooxazole) (CAS 499786-37-7)
- Semaglutide impurity 109 (CAS CATO-C4X-2226109)
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