Crisaborole lmpurity 74 CAS CATO-C4X-202174
| CAS No. | CATO-C4X-202174 |
| Molecular Formula | C21H14BrNO4 |
| Molecular Weight | 424.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Crisaborole lmpurity 74 (CAS CATO-C4X-202174, C21H14BrNO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Crisaborole lmpurity 74 (C21H14BrNO4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C21H14BrNO4 |
| Molecular Weight | 424.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Crisaborole Standards
- Crisaborole lmpurity 75 (CAS CATO-C4X-202175)
- Crisaborole impurity 110 (CAS CATO-C4X-2021110)
- Crisaborole Impurity 20 (CAS CATO-C4X-202120)
- Crisaborole Impurity 21 (CAS CATO-C4X-202121)
- Crisaborole Impurity 146 (CAS CATO-C4X-2021146)
- Crisaborole impurity 123 (CAS CATO-C4X-2021123)
- Crisaborole Impurity 50 (CAS CATO-C4X-202150)
- Crisaborole Impurity 137 (CAS CATO-C4X-2021137)
Recommended Standards
- (4,4-Difluorocyclohexanethiolato-κS)(trimethylphosphine)gold (CAS 2098859-80-2)
- tert-butyl N-[5-bromo-4-(difluoromethyl)pyrimidin-2-yl]-N-tert-butoxycarbonyl-carbamate (CAS 1927858-81-8)
- 4,4'-(Perfluoropropane-2,2-diyl)bis(2-nitroaniline) (CAS 1174-51-2)
- tert-Butyl (5-bromo-4-(4-(trifluoromethyl)thiazol-2-yl)pyridin-2-yl)carbamate (CAS 1186111-35-2)
- Levodopa EP Impurity C-d3 (S-isomer) (L-3-O-Methyldopa-d3) (CAS 586954-09-8)
- Sodium Cromoglicate Impurity 8 (CAS 16130-28-2)
- Tafluprost Impurity 15 (CAS 209861-00-7)
- (R)-N-(1-(3-Bromophenyl)ethylidene)-2-methylpropane-2-sulfinamide (CAS 1076160-64-9)
- 2-(2-Bromoethyl)pyridazin-3(2H)-one (CAS 83675-79-0)
- 3-(Methylsulfanyl)-5-[(E)-2-(phenylamino)ethenyl]-1,2-thiazole-4-carbonitrile (CAS 338417-45-1)
- Ethyl 3-amino-4-{[2-(dimethylamino)ethyl]-amino}benzoate (CAS 1220035-46-0)
- 2,2,3,3-Tetramethylbutanoic acid (CAS 30407-41-1)
- Bis(2-chlorophenyl)methanone (CAS 5293-97-0)
- Tirzepatide Impurity 47 (CAS CATO-C4X-324047)
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