Osimertinib Impurity 109 CAS CATO-C4X-2045109
| CAS No. | CATO-C4X-2045109 |
| Molecular Formula | C56H67N14O4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Osimertinib Impurity 109 is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Osimertinib Impurity 109 (CAS CATO-C4X-2045109), a pharmacopoeial impurity reference standard (molecular formula C56H67N14O4C2HF3O2C2F3O2, MW 1227.28 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Osimertinib Impurity 109 (C56H67N14O4C2HF3O2C2F3O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 31.0, corresponding to approximately 31 ring(s) or double-bond equivalent(s). With a molecular weight of 1227.28 g/mol, it falls into the high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Osimertinib Impurity 109 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C56H67N14O4 2*C2HF3O2 C2F3O2 |
| Molecular Weight | 1227.28 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 31.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 14 |
Related Osimertinib Standards
- Osimertinib Impurity 5 (CAS 1009298-59-2)
- Osimertinib Impurity 8 (CAS 1421372-66-8)
- Osimertinib Impurity N1 (CAS 1421372-67-9)
- Osimertinib Impurity N2 (CAS 1421373-36-5 (free base))
- Osimertinib (CAS 1421373-65-0)
- Osimertinib Impurity 10 (CAS 1421373-98-9)
- Osimertinib Impurity N3 (CAS 1421373-99-0)
- Osimertinib-3 (CAS 1446700-26-0)
Recommended Standards
- Teneligliptin Impurity 13 (CAS 1404559-17-6)
- Dolasetron Impurity 2 (CAS 127951-99-9)
- Captopril EP Impurity C (CAS 26473-47-2)
- 3-(2,4-Difluorophenyl)-5,6-dihydro-4H-pyrrolo[3,2-d]isoxazole (CAS 603067-91-0)
- 4-Bromo-5-ethyl-3-(trifluoromethyl)-1H-Pyrazole (CAS 1417982-47-8)
- N-(6-Chloropyrazin-2-yl)-2-(hydroxymethyl)pyrrolidine-1-carboxamide hydrochloride (CAS 1417793-82-8)
- 4-(4-Fluoro-3-((pyridin-2-ylmethyl)carbamoyl)phenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide (CAS 1813527-81-9)
- 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide (CAS 302964-24-5)
- 2-cyano-N-(2-pyrazinyl)acetamide (CAS 90158-75-1)
- [5-31]-Semaglutide (CAS CATO-C4X-2226263)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com