Roflumilast Impurity 11 CAS CATO-C4X-204711
| CAS No. | CATO-C4X-204711 |
| Molecular Formula | C22H28Cl2N2O8S2 |
| Molecular Weight | 583.50 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Roflumilast Impurity 11 (CAS CATO-C4X-204711), a pharmacopoeial impurity reference standard (molecular formula C22H28Cl2N2O8S2, MW 583.50 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Roflumilast Impurity 11 (C22H28Cl2N2O8S2) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 583.50 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H28Cl2N2O8S2 |
| Molecular Weight | 583.50 g/mol |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 2 |
Related Roflumilast Standards
- Roflumilast Impurity 12 (CAS CATO-C4X-204712)
- Roflumilast Impurity 8 (CAS CATO-C4X-10848)
- Roflumilast Impurity 48 (CAS CATO-C4X-108448)
- Roflumilast Dimer (CAS 1352122-37-2)
- Roflumilast Impurity 47 (CAS CATO-C4X-108447)
- Roflumilast Impurity 46 (CAS CATO-C4X-108446)
- Roflumilast Impurity 59 (CAS CATO-C4X-193559)
- Roflumilast USP Related Compound E (CAS 3031785-18-6)
Recommended Standards
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