Ruxolitinib impurity 48 CAS CATO-C4X-205848
| CAS No. | CATO-C4X-205848 |
| Molecular Formula | C6H4N4O2 |
| Molecular Weight | 164.12 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Ruxolitinib impurity 48 (C6H4N4O2) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies Ruxolitinib impurity 48 (CAS CATO-C4X-205848), a pharmacopoeial impurity reference standard (molecular formula C6H4N4O2, MW 164.12 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Ruxolitinib impurity 48 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H4N4O2 |
| Molecular Weight | 164.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 4 |
Related Ruxolitinib Standards
- Ruxolitinib Impurity 232 (CAS CATO-C4X-2058232)
- Ruxolitinib Impurity 109 (CAS CATO-C4X-2058109)
- Ruxolitinib Impurity 87 (CAS CATO-C4X-205887)
- Ruxolitinib Impurity 13 (CAS 1865785-69-8)
- Ruxolitinib impurity 227 (CAS 350483-64-6)
- Ruxolitinib Impurity 60 (CAS CATO-C4X-205860)
- Ruxolitinib Impurity 59 (CAS 2802349-76-2)
- Ruxolitinib Impurity 37 (CAS 2821844-77-1)
Recommended Standards
- Trazodone Impurity 43 (CAS CATO-C4X-177243)
- N-Nitroso Adenine (CAS 2615274-45-6)
- Allopurinol impurity 26 (CAS CATO-C4X-145826)
- (3S,4S,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyldihydrofuran-2(3H)-one (CAS 1033394-92-1)
- Bumetanide Impurity 63 (CAS CATO-C4X-198663)
- Azilsartan Impurity 95 (CAS CATO-C4X-109695)
- Ezetimibe Impurity 34 (CAS 99395-88-7)
- 9-Methyl-9H-purine-6-carboxylic acid (CAS 1095822-37-9)
- Glycine-d5 (CAS 4896-77-9)
- (R)-3-(2-Methylpyrrolidin-1-yl)aniline (CAS 1427514-94-0)
- Vonoprazan Impurity N27 (CAS 24367-50-8)
- Ethyl 5-amino-6-chloropyrazolo[1,5-a]pyridine-3-carboxylate (CAS 1951428-42-4)
- Ethyl 2-(ethylamino)acetate hydrochloride (CAS 3183-13-9)
- Insulin Degludec Impurity 14 (CAS CATO-C4X-215714)
Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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