Lusutrombopag Impurity 27 CAS CATO-C4X-208427

Purity 97%+In StockPharmacopoeial Impurity Standards
CAS No.CATO-C4X-208427
Molecular FormulaC11H16O3
Molecular Weight196.24 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Lusutrombopag Impurity 27 CAS CATO-C4X-208427 chemical structure

Description

Lusutrombopag Impurity 27 (CAS CATO-C4X-208427) is a certified pharmaceutical impurity reference standard with the molecular formula C11H16O3 and a molecular weight of 196.24 g/mol.

Lusutrombopag Impurity 27 (C11H16O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC11H16O3
Molecular Weight196.24 g/mol
AppearanceOff-white to pale yellow crystalline powder
Purity97%+
StorageStore at 2-8°C, keep sealed and dry
Solubility (reference)Soluble in methanol, ethanol, DMSO
StabilityMay oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening
Degree of Unsaturation (DBE)4.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present

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