Lusutrombopag Impurity 74 CAS CATO-C4X-208474
| CAS No. | CATO-C4X-208474 |
| Molecular Formula | C8H4Cl2O3 |
| Molecular Weight | 219.02 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Lusutrombopag Impurity 74 (CAS CATO-C4X-208474, C8H4Cl2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Lusutrombopag Impurity 74 (C8H4Cl2O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H4Cl2O3 |
| Molecular Weight | 219.02 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
Related Lusutrombopag Standards
- Lusutrombopag Impurity 42 (CAS 1367365-00-1)
- Lusutrombopag Impurity 44 (CAS 2126856-49-1)
- Lusutrombopag Impurity 73 (CAS CATO-C4X-208473)
- Lusutrombopag Impurity 75 (CAS CATO-C4X-208475)
- Lusutrombopag Impurity 76 (CAS CATO-C4X-208476)
- Lusutrombopag Impurity N2 (CAS 89894-53-1)
- Lusutrombopag Impurity 4 (CAS CATO-C4X-20844)
- Lusutrombopag Impurity N5 (CAS 29841-69-8)
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