Nicergoline Impurity 28 CAS CATO-C4X-208528
| CAS No. | CATO-C4X-208528 |
| Molecular Formula | C24H26BrN3O4 |
| Molecular Weight | 500.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 500.38 g/mol gives Nicergoline Impurity 28 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Nicergoline Impurity 28 (CAS CATO-C4X-208528) is a certified pharmaceutical impurity reference standard with the molecular formula C24H26BrN3O4 and a molecular weight of 500.38 g/mol.
Nicergoline Impurity 28 (C24H26BrN3O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H26BrN3O4 |
| Molecular Weight | 500.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 3 |
Related Nicergoline Standards
- Nicergoline Impurity 17 (CAS CATO-C4X-208517)
- Nicergoline Impurity 27 (CAS 2061916-37-6)
- Nicergoline-13C-d3 (CAS CATO-C4X-208513)
- Nicergoline (CAS 27848-84-6)
- Nicergoline Impurity 26 (CAS CATO-C4X-208526)
- Nicergoline EP Impurity F (CAS 58001-19-7)
- Nicergoline Impurity 29 (CAS CATO-C4X-208529)
- Nicergoline Impurity 15 (CAS CATO-C4X-208515)
Recommended Standards
- 3-((4-Bromophenyl)sulfonyl)-N-(m-tolyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-amine (CAS 892749-88-1)
- Diethyl 1-(3,5-bis(trifluoromethyl)phenyl)-5-phenyl-1H-pyrazole-3,4-dicarboxylate (CAS 96722-93-9)
- Apixaban Impurity 51 (CAS CATO-C4X-108851)
- N-(4-Chloro-2-methoxy-5-methylphenyl)-2-((4-(4-chlorophenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 476483-99-5)
- Posaconazole Impurity 155 (CAS CATO-C4X-1208155)
- Bumetanide Impurity 14 (CAS 118-97-8)
- Bumetanide Impurity 41 (CAS 20532-06-3)
- 5-(Chloromethyl)pyridin-2-amine (CAS 230617-81-9)
- 1-{2-[(3-methylpiperidin-1-yl)methyl]phenyl}methanamine (CAS 926209-68-9)
- 2-Bromo-4-fluoro-6-(trifluoromethyl)pyridine (CAS 1227577-12-9)
- tert-Butyl (S)-3-(3-methoxyphenyl)piperazine-1-carboxylate (CAS 1228571-11-6)
- Tucatinib Impurity 35 (CAS CATO-C4X-260535)
- 2,5-Dimethylindoline (CAS 90874-56-9)
- Semaglutide Impurity 161 (x TFA Salt) (CAS CATO-C4X-2226161)
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