Dacomitinib Impurity 27 CAS CATO-C4X-208627
| CAS No. | CATO-C4X-208627 |
| Molecular Formula | C18H17ClFN5O |
| Molecular Weight | 373.81 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Dacomitinib Impurity 27 (CAS CATO-C4X-208627) is a certified pharmaceutical impurity reference standard with the molecular formula C18H17ClFN5O and a molecular weight of 373.81 g/mol.
Dacomitinib Impurity 27 (C18H17ClFN5O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H17ClFN5O |
| Molecular Weight | 373.81 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related Dacomitinib Standards
- Dacomitinib Impurity 41 (CAS CATO-C4X-208641)
- Dacomitinib Impurity 36 (CAS CATO-C4X-208636)
- Dacomitinib Impurity 33 (CAS CATO-C4X-208633)
- Dacomitinib Impurity 30 (CAS CATO-C4X-208630)
- Dacomitinib Impurity 39 (CAS CATO-C4X-208639)
- Dacomitinib Impurity 26 (CAS CATO-C4X-208626)
- Dacomitinib Impurity N4 (CAS 2190490-31-2)
- Dacomitinib Impurity 29 (CAS CATO-C4X-208629)
Recommended Standards
- N-(2-(2-chlorobenzoyl)-3-oxo-2,3-dihydro-1,2,4-thiadiazol-5-yl)-4-methylbenzamide (CAS 478031-94-6)
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- Methyl 1-(4-chlorophenyl)-6-oxo-4-(pyridin-2-ylsulfanyl)-1,6-dihydropyridazine-3-carboxylate (CAS 338405-50-8)
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- 3-(Boc-amino)-2-azepanone (CAS 179686-45-4)
- Tetrahydrofuran-2,5-diol (CAS 133200-67-6)
- N-((4-amino-2-propylpyrimidin-5-yl)methyl)butyramide (CAS 725-46-2)
- 6,6,7,7,8,8,8-Heptafluoro-2-methyloctane-3,5-dione (CAS 40002-62-8)
- 4-(3-Fluorophenyl)-5-(methylsulfonyl)thiazol-2-amine (CAS 1707605-68-2)
- 6-Chloro-3-(4-chlorobenzenesulfonyl)-2H-chromen-2-one (CAS 866013-21-0)
- [His]1+12-Semaglutide (CAS CATO-C4X-2226178)
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