Dacomitinib Impurity 30 CAS CATO-C4X-208630
| CAS No. | CATO-C4X-208630 |
| Molecular Formula | C15H10ClFN4O3 |
| Molecular Weight | 348.72 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Dacomitinib Impurity 30 (C15H10ClFN4O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies Dacomitinib Impurity 30 (CAS CATO-C4X-208630), a pharmacopoeial impurity reference standard (molecular formula C15H10ClFN4O3, MW 348.72 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Dacomitinib Impurity 30 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H10ClFN4O3 |
| Molecular Weight | 348.72 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Dacomitinib Standards
- Dacomitinib Impurity 39 (CAS CATO-C4X-208639)
- Dacomitinib Impurity 26 (CAS CATO-C4X-208626)
- Dacomitinib Impurity 29 (CAS CATO-C4X-208629)
- Dacomitinib Impurity 36 (CAS CATO-C4X-208636)
- Dacomitinib Impurity 41 (CAS CATO-C4X-208641)
- Dacomitinib Impurity 27 (CAS CATO-C4X-208627)
- Dacomitinib Impurity 31 (CAS CATO-C4X-208631)
- Dacomitinib Impurity 4 (CAS 179552-75-1)
Recommended Standards
- Afatinib Impurity 41 (CAS 179552-74-0)
- N-(3-Chloro-2-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine (Dacomitinib Impurity) (CAS 1454307-45-9)
- Methyl 3-(4-Chlorophenyl)-1-(2,4-difluorophenyl)-1H-pyrazole-5-carboxylate (CAS 1202028-92-9)
- N1-[3-(1H-imidazol-1-yl)propyl]-5-chloro-2-nitro-4-(trifluoromethyl)aniline (CAS 647824-52-0)
- Halometasone Impurity N1 (CAS 136132-00-8)
- Ibrutinib Impurity 59 (CAS CATO-C4X-106459)
- Relebactam Impurity 28 (CAS CATO-C4X-214428)
- Dexamethasone Impurity 117 (CAS CATO-C4X-1165117)
- 1-(2-Methoxyacetamido)cyclohexane-1-carboxylic acid (CAS 652172-86-6)
- (3-Aminoazetidin-1-yl)(5-methylpyrazin-2-yl)methanone (CAS 1481104-50-0)
- 1-(2-Methoxyethyl)-1H-imidazole-2-carbonitrile (CAS 1449144-34-6)
- (1-(tert-butoxycarbonyl)-4-(diisopropylcarbamoyl)-1H-indol-2-yl)boronic acid (CAS 953411-04-6)
- 2-Selenoxo-2,3-dihydropyrimidin-4(1H)-one (CAS 16724-03-1)
- Osteogenic Growth Peptide (10-14) (CAS 105250-85-9)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com