Dacomitinib Impurity 45 CAS CATO-C4X-208645
| CAS No. | CATO-C4X-208645 |
| Molecular Formula | C23H22Cl2FN5O |
| Molecular Weight | 474.36 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Dacomitinib Impurity 45 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Dacomitinib Impurity 45 (CAS CATO-C4X-208645, C23H22Cl2FN5O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Dacomitinib Impurity 45 (C23H22Cl2FN5O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C23H22Cl2FN5O |
| Molecular Weight | 474.36 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related Dacomitinib Standards
- Dacomitinib Impurity 47 (CAS CATO-C4X-208647)
- Dacomitinib (CAS 1110813-31-4)
- Dacomitinib Impurity 28 (CAS CATO-C4X-208628)
- Dacomitinib Impurity 32 (CAS CATO-C4X-208632)
- Dacomitinib Impurity 38 (CAS CATO-C4X-208638)
- Dacomitinib Impurity 7 (CAS CATO-C4X-20867)
- Dacomitinib Impurity 9 (CAS CATO-C4X-20869)
- Dacomitinib Impurity 51 (CAS CATO-C4X-208651)
Recommended Standards
- (9,10-Di(naphthalen-2-yl)anthracen-2-yl)boronic acid (CAS 867044-28-8)
- Cichoric Acid (CAS 6537-80-0)
- (9,10-Di(naphthalen-1-yl)anthracen-2-yl)boronic acid (CAS 867044-35-7)
- L-Chicoric Acid (CAS 70831-56-0)
- Roflumilast impurity 23 (CAS 1369817-76-4)
- Lifitegrast Impurity 157 (CAS CATO-C4X-2409157)
- Sitagliptin Impurity 966 (CAS 1151240-88-8)
- 2-Propoxybenzaldehyde (CAS 7091-12-5)
- ethyl 2-(1H-imidazol-2-yl)acetate (CAS 791569-71-6)
- Dichloro(1-phenyl-1,2-ethanediamine-N,N')platinum (CAS 80339-76-0)
- tert-Butyl 3-hydrazinylpiperidine-1-carboxylate dihydrochloride (CAS 1628179-35-0)
- (5-Fluorobiphenyl-2-yl)methanamine (CAS 1002557-11-0)
- Simcp (CAS 850221-63-5)
- Des-His(1)-Semaglutide (CAS CATO-C4X-2226216)
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