Dacomitinib Impurity 10 CAS CATO-C4X-208610
| CAS No. | CATO-C4X-208610 |
| Molecular Formula | C23H22ClF2N5O |
| Molecular Weight | 457.90 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 457.90 g/mol gives Dacomitinib Impurity 10 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Dacomitinib Impurity 10 (CAS CATO-C4X-208610) is a certified pharmaceutical impurity reference standard with the molecular formula C23H22ClF2N5O and a molecular weight of 457.90 g/mol.
Structurally, Dacomitinib Impurity 10 (C23H22ClF2N5O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 14.0, corresponding to approximately 14 ring(s) or double-bond equivalent(s). With a molecular weight of 457.90 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Dacomitinib Impurity 10 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C23H22ClF2N5O |
| Molecular Weight | 457.90 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related Dacomitinib Standards
- Dacomitinib Impurity 8 (CAS CATO-C4X-20868)
- Dacomitinib Impurity 35 (CAS CATO-C4X-208635)
- Dacomitinib (CAS 1110813-31-4)
- Dacomitinib Impurity 28 (CAS CATO-C4X-208628)
- Dacomitinib Impurity 32 (CAS CATO-C4X-208632)
- Dacomitinib Impurity 38 (CAS CATO-C4X-208638)
- Dacomitinib Impurity 7 (CAS CATO-C4X-20867)
- Dacomitinib Impurity 9 (CAS CATO-C4X-20869)
Recommended Standards
- 2-(1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperidine-4-carbonyl)-N-phenylhydrazine-1-carbothioamide (CAS 321430-55-1)
- 4-Chloro-2-methylbenzyl 4-(3-oxo-3-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)propyl)piperazine-1-carboxylate (CAS 1144035-27-7)
- (E)-[(4-{[(4-chlorophenyl)methyl]sulfanyl}-3-nitrophenyl)methylidene][(4-nitrophenyl)methoxy]amine (CAS 303996-27-2)
- 4-Chlorobenzyl 4-(3-(5-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)-3-oxopropyl)piperazine-1-carboxylate (CAS 1144035-43-7)
- Galantamine EP Impurity E HBr (CAS 1201809-28-0)
- Icaritin Impurity 12 (CAS CATO-C4X-276412)
- Phentolamine Impurity 25 (CAS CATO-C4X-224725)
- 4-Isopropyl-6-(methylthio)-1,3,5-triazin-2-amine (CAS 175204-55-4)
- (S)-1-(4-Fluorophenyl)ethanol (CAS 101219-73-2)
- 2-Amino-3-methyl-6-(trifluoromethyl)pyrimidin-4(3H)-one (CAS 216016-31-8)
- (4-Nitrophenyl)glycine (CAS 619-91-0)
- CErium molybdenum oxide (Ce2Mo3O12) (CAS 13454-70-1)
- Boc-(R)-3-Amino-5-hexenoic acid (CAS 269726-94-5)
- Antistasin-Related Peptide (CAS 161561-46-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com