Roxadustat Impurity 130 CAS CATO-C4X-2213130
| CAS No. | CATO-C4X-2213130 |
| Molecular Formula | C21H19N3O6 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Roxadustat Impurity 130 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Roxadustat Impurity 130 (CAS CATO-C4X-2213130, C21H19N3O6HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Roxadustat Impurity 130 (C21H19N3O6HCl) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Roxadustat Impurity 130 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C21H19N3O6 HCl |
| Molecular Weight | 445.86 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Roxadustat Standards
- Roxadustat Impurity N6 (CAS 1421312-32-4)
- Roxadustat Impurity N4 (CAS 1421312-33-5)
- Roxadustat Impurity N3 (CAS 1421312-34-6)
- Roxadustat Impurity 9 (CAS 1421312-35-7)
- Roxadustat Impurity 5 (CAS 1421312-36-8)
- Roxadustat Impurity 33 (CAS 1455091-04-9)
- Roxadustat Impurity 7 (CAS 1455091-06-1)
- Roxadustat Impurity N15 (CAS 1455091-10-7)
Recommended Standards
- Beraprost Impurity 13 (CAS CATO-C4X-218413)
- Glipizide Impurity 36 (CAS 933705-21-6)
- Telmisartan Impurity 59 (CAS 1016696-74-4)
- Amlodipine Impurity 43 (CAS CATO-C4X-109543)
- 3-(Isobutylthio)benzaldehyde (CAS 1443343-56-3)
- 3-methylene-1-(4-methylphenyl)dihydro-1H-pyrrole-2,5-dione (CAS 74216-90-3)
- 4-iodo-1-N-methylbenzene-1,2-diamine dihydrochloride (CAS 1864073-55-1)
- Ethyl 3-amino-5-fluoroisonicotinate (CAS 1569308-91-3)
- 2-(4-Ethynyl-1H-pyrazol-1-yl)-N,N-dimethylacetamide (CAS 1400287-31-1)
- Tirzepatide Impurity 46 (CAS CATO-C4X-324046)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com