Roxadustat Impurity 137 CAS CATO-C4X-2213137

Description

The occurrence of Roxadustat Impurity 137 is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, a polycyclic aromatic system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

Roxadustat Impurity 137 (CAS CATO-C4X-2213137) is a certified pharmaceutical impurity reference standard with the molecular formula C14H11BrO3 and a molecular weight of 307.14 g/mol.

Based on its molecular formula C14H11BrO3, Roxadustat Impurity 137 contains a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, a polycyclic aromatic system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 307.14 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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