Avatrombopag Impurity 112 CAS CATO-C4X-2234112
| CAS No. | CATO-C4X-2234112 |
| Molecular Formula | C15H18ClN3O2S2 |
| Molecular Weight | 371.91 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Avatrombopag Impurity 112 (CAS CATO-C4X-2234112) is a certified pharmaceutical impurity reference standard with the molecular formula C15H18ClN3O2S2 and a molecular weight of 371.91 g/mol.
Avatrombopag Impurity 112 (C15H18ClN3O2S2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Avatrombopag Impurity 112 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H18ClN3O2S2 |
| Molecular Weight | 371.91 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 2 |
Related Avatrombopag Standards
- Avatrombopag impurity 130 (CAS CATO-C4X-2234130)
- Avatrombopag impurity 135 (CAS CATO-C4X-2234135)
- Avatrombopag Impurity 9 (CAS 2401867-89-6)
- Avatrombopag Impurity 107 (CAS CATO-C4X-2234107)
- Avatrombopag Impurity 127 (CAS CATO-C4X-2234127)
- Avatrombopag Impurity 25 (CAS CATO-C4X-223425)
- Avatrombopag Impurity 30 (CAS 570407-42-0)
- Avatrombopag impurity 132 (CAS CATO-C4X-2234132)
Recommended Standards
- 5-Bromo-2-iodo-3-nitrobenzoic acid (CAS 855749-52-9)
- 4-Chloro-N-(5-(2-(pyrrolidin-1-yl)ethyl)thiazol-2-yl)benzenesulfonamide (CAS 71933-37-4)
- N-(4-chlorophenyl)-4-cinnamylpiperazine-1-carbothioamide (CAS 431891-08-6)
- 2,6-Diiodo-7H-purine (CAS 98027-95-3)
- Furazolidone Impurity 10 (CAS CATO-C4X-290110)
- Ruxolitinib Impurity 27 (CAS CATO-C4X-205827)
- Eltrombopag Impurity 40 (CAS 591-17-3)
- (R)-3-(tert-Butyl)-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrazol-5-amine (CAS 1141016-83-2)
- 3-(Azetidin-3-yl)propan-1-ol;hydrochloride (CAS 1379237-95-2)
- Ethyl 7-Oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate (CAS 29274-18-8)
- 1-(Cyclopropylmethyl)-1,8-diazaspiro[4.5]Decan-2-one (CAS 1385696-33-2)
- 4-CHloro-n-(4-methylphenyl)benzenesulfonamide (CAS 4279-74-7)
- 5-Bromo-2-(trimethylsilyl)pyridine (CAS 291312-74-8)
- Polymyxin B nonapeptide (CAS 86408-36-8)
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