Avatrombopag impurity 135 CAS CATO-C4X-2234135

Purity 97%+In StockPharmacopoeial Impurity Standards
CAS No.CATO-C4X-2234135
Molecular FormulaC7H3Br2ClN2S2
Molecular Weight374.50 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Avatrombopag impurity 135 CAS CATO-C4X-2234135 chemical structure

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Avatrombopag impurity 135.

Avatrombopag impurity 135 (CAS CATO-C4X-2234135) is a certified pharmaceutical impurity reference standard with the molecular formula C7H3Br2ClN2S2 and a molecular weight of 374.50 g/mol.

The molecular framework of Avatrombopag impurity 135 (C7H3Br2ClN2S2) is characterized by a nitrile group, sulfur-containing functionality, chlorine/bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

As a certified reference material (CRM), Avatrombopag impurity 135 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC7H3Br2ClN2S2
Molecular Weight374.50 g/mol
Purity97%+
StorageStore at 2-8°C, protect from light
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)6.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
Halogen ContentCl/Br-containing
Nitrogen Atoms2
Sulfur Atoms2

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