Baricitinib Impurity 120 CAS CATO-C4X-2260120
| CAS No. | CATO-C4X-2260120 |
| Molecular Formula | C14H14N6O2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Baricitinib Impurity 120.
CATO supplies Baricitinib Impurity 120 (CAS CATO-C4X-2260120), a pharmacopoeial impurity reference standard (molecular formula C14H14N6O2C2HF3O2, MW 412.33 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C14H14N6O2C2HF3O2, Baricitinib Impurity 120 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 412.33 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Baricitinib Impurity 120 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H14N6O2 C2HF3O2 |
| Molecular Weight | 412.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 6 |
Related Baricitinib Standards
- Baricitinib Impurity 21 (CAS 1024120-52-2)
- Baricitinib Impurity 14 (CAS 1029716-44-6)
- Baricitinib Impurity 23 (CAS 1146629-75-5)
- Baricitinib Impurity 39 (CAS 1146629-76-6)
- Baricitinib Impurity 42 (CAS 1146629-77-7)
- Baricitinib Impurity 18 (CAS 1153949-11-1)
- Baricitinib Impurity N5 (CAS 1153949-15-5)
- Baricitinib (CAS 1187594-09-7)
Recommended Standards
- Fosfomycin Impurity 42 (CAS 45629-00-3（free base）)
- Roxatidine Impurity 21 (CAS 108441-34-5)
- Minocycline EP Impurity G (CAS 601455-95-2)
- 4-(2-Chloro-4-(4-chlorophenoxy)phenyl)thiazol-2-amine (CAS 338756-39-1)
- (5-CHLORO-2-NITROPHENYL)METHANOL 4-CHLORO-2-(HYDROXYMETHYL)NITROBENZENE 5-CHLORO-2-NITROBENZENEMETHANOL 5-Chloro-2-nitrobenzyl alcohol 73033-58-6 AS05960 BENZENEMETHANOL, 5-CHLORO-2-NITRO- (CAS 73033-58-6)
- (1R,4R,6S)-2-(tert-butoxycarbonyl)-2-azabicyclo[2.2.1]Heptane-6-carboxylic acid (CAS 1627973-08-3)
- 7,7-Difluorobicyclo[4.1.0]heptan-3-amine hydrochloride (CAS 1955493-70-5)
- 1-(6-methylpyridazin-3-yl)-1,4-diazepane dihydrobromide (CAS 1311317-17-5)
- methyl 2-(oxolan-3-yl)acetate (CAS 910565-30-9)
- Semaglutide Impurity 145 (CAS CATO-C4X-2226145)
Why CATO?
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