Baricitinib Impurity 121 CAS CATO-C4X-2260121
| CAS No. | CATO-C4X-2260121 |
| Molecular Formula | C7H11NO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Baricitinib Impurity 121.
Baricitinib Impurity 121 (CAS CATO-C4X-2260121) is a certified pharmaceutical impurity reference standard with the molecular formula C7H11NO2C2HF3O2 and a molecular weight of 255.19 g/mol.
The molecular framework of Baricitinib Impurity 121 (C7H11NO2C2HF3O2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Baricitinib Impurity 121 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H11NO2 C2HF3O2 |
| Molecular Weight | 255.19 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Baricitinib Standards
- Baricitinib Impurity 21 (CAS 1024120-52-2)
- Baricitinib Impurity 14 (CAS 1029716-44-6)
- Baricitinib Impurity 23 (CAS 1146629-75-5)
- Baricitinib Impurity 39 (CAS 1146629-76-6)
- Baricitinib Impurity 42 (CAS 1146629-77-7)
- Baricitinib Impurity 18 (CAS 1153949-11-1)
- Baricitinib Impurity N5 (CAS 1153949-15-5)
- Baricitinib (CAS 1187594-09-7)
Recommended Standards
- Moxifloxacin Impurity 90 (CAS 765-30-0)
- Netupitant Impurity 24 (CAS 1314722-26-3)
- Tetracaine Impurity 21 (CAS CATO-C4X-192321)
- 5-(Naphthalen-2-yl)oxazol-2-amine (CAS 1347697-79-3)
- 3-((4-Chlorobenzyl)thio)-5-(((2,6-dichlorobenzyl)thio)methyl)-4-phenyl-4H-1,2,4-triazole (CAS 344271-34-7)
- cis-Tetrahydro-furan-3,4-dicarboxylic acid (CAS 149429-49-2)
- N-(3-Isopropoxybenzyl)-3-(2-methoxyethoxy)aniline (CAS 1040686-79-0)
- 4,7-Dichlorobenzo[b]thiophene (CAS 318463-07-9)
- Tetrabenazine Impurity 31-D3 (CAS CATO-C4X-274831)
- Smac-N7 Peptide (CAS 401913-57-3)
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