Ponatinib Impurity 21 CAS CATO-C4X-226921
| CAS No. | CATO-C4X-226921 |
| Molecular Formula | C21H22F3I2N3O |
| Molecular Weight | 643.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Ponatinib Impurity 21 (CAS CATO-C4X-226921) is a certified pharmaceutical impurity reference standard with the molecular formula C21H22F3I2N3O and a molecular weight of 643.23 g/mol.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/iodine substitution, Ponatinib Impurity 21 is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 643.23 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Ponatinib Impurity 21 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H22F3I2N3O |
| Molecular Weight | 643.23 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/I-containing |
| Nitrogen Atoms | 3 |
Related Ponatinib Standards
- Ponatinib Impurity 22 (CAS CATO-C4X-226922)
- Ponatinib Impurity 25 (CAS CATO-C4X-226925)
- Ponatinib Impurity 58 (CAS CATO-C4X-226958)
- Ponatinib Impurity 14 (CAS CATO-C4X-226914)
- Ponatinib Impurity 17 (CAS CATO-C4X-226917)
- Ponatinib Metabolite AP-24567 N-Glucuronide (Amadori Rearrangement Product) (CAS CATO-C4X-226926)
- Ponatinib Impurity 29 (CAS CATO-C4X-226929)
- Ponatinib Impurity 55 (CAS CATO-C4X-226955)
Recommended Standards
- Calcipotriol Impurity 18 (CAS 2229745-37-1)
- Avatrombopag Impurity 142 (CAS CATO-C4X-2234142)
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- Roflumilast Dimer (CAS 1352122-37-2)
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- Febuxostat Impurity 29 (CAS 144060-62-8)
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- 5-((2-(3-Bromophenoxy)ethyl)thio)-1,3,4-thiadiazol-2-amine (CAS 735323-91-8)
- 5-Isobutyl-3-(2-methylbutyl)-2H-pyrrole-2,4(3H)-dione (CAS 496941-94-7)
- 4-{[(furan-2-ylmethyl)amino]methyl}phenol (CAS 478358-10-0)
- Ethyl (S)-3-amino-3-(p-tolyl)propanoate (CAS 219813-90-8)
- 1-(3-(4-Chlorophenoxy)phenyl)urea (CAS 1956379-24-0)
- Prolactin-Releasing Peptide (1-31) (rat) (CAS 215510-06-8)
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