Ponatinib Impurity 55 CAS CATO-C4X-226955
| CAS No. | CATO-C4X-226955 |
| Molecular Formula | C29H28ClF3N6O |
| Molecular Weight | 569.02 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Ponatinib Impurity 55 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Ponatinib Impurity 55 (CAS CATO-C4X-226955) is a certified pharmaceutical impurity reference standard with the molecular formula C29H28ClF3N6O and a molecular weight of 569.02 g/mol.
Ponatinib Impurity 55 (C29H28ClF3N6O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C29H28ClF3N6O |
| Molecular Weight | 569.02 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 6 |
Related Ponatinib Standards
- Ponatinib Impurity 59 (CAS CATO-C4X-226959)
- Ponatinib Impurity 29 (CAS CATO-C4X-226929)
- Ponatinib Impurity 28 (CAS CATO-C4X-226928)
- Ponatinib Impurity 10 (CAS CATO-C4X-226910)
- Ponatinib impurity 6 (CAS 2227480-51-3)
- Ponatinib Impurity 11 (CAS CATO-C4X-226911)
- Ponatinib-d8 (CAS 1562993-37-6)
- Ponatinib Impurity 14 (CAS CATO-C4X-226914)
Recommended Standards
- Encorafenib Impurity 4 (CAS CATO-C4X-32494)
- 3-(2,5,7-Tribromo-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid (CAS 93798-31-3)
- Formocortal (CAS 2825-60-7)
- Cholesteryl dodecanoate (CAS 1908-11-8)
- Posaconazole Impurity 161 (CAS CATO-C4X-1208161)
- Mianserin Impurity 58 (CAS CATO-C4X-136958)
- Norethisterone EP Impurity F (CAS 96487-85-3)
- 6-[(2-Aminoethyl)amino]pyridine-3-carboxylic acid (CAS 904815-02-7)
- 2-(Propylthio)nicotinic acid (CAS 175135-22-5)
- (See C4X-107915)Tofacitinib Impurity 44 (CAS CATO-C4X-107944)
- 1-cyclohexylcyclopropane-1-carboxylic acid (CAS 803736-51-8)
- 6-Chloro-2-cyano-5-(difluoromethyl)nicotinic acid (CAS 1805970-81-3)
- 2-((2-(Furan-2-yl)-2-oxoethylidene)amino)benzenesulfonic acid (CAS 88847-01-2)
- D-Leu14-Tirzepatide (CAS CATO-CPTD788920)
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