Ponatinib Impurity 58 CAS CATO-C4X-226958
| CAS No. | CATO-C4X-226958 |
| Molecular Formula | C37H32F3N9O |
| Molecular Weight | 675.70 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Ponatinib Impurity 58 (CAS CATO-C4X-226958, C37H32F3N9O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C37H32F3N9O, Ponatinib Impurity 58 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 675.70 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Ponatinib Impurity 58 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C37H32F3N9O |
| Molecular Weight | 675.70 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 25.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 9 |
Related Ponatinib Standards
- Ponatinib Impurity 25 (CAS CATO-C4X-226925)
- Ponatinib Impurity 22 (CAS CATO-C4X-226922)
- Ponatinib Impurity 17 (CAS CATO-C4X-226917)
- Ponatinib Metabolite AP-24567 N-Glucuronide (Amadori Rearrangement Product) (CAS CATO-C4X-226926)
- Ponatinib Impurity 21 (CAS CATO-C4X-226921)
- Ponatinib Impurity 14 (CAS CATO-C4X-226914)
- Ponatinib Impurity 29 (CAS CATO-C4X-226929)
- Ponatinib Impurity 55 (CAS CATO-C4X-226955)
Recommended Standards
- N-(9-((2R,3S,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide (CAS 226415-08-3)
- 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(((2R,3S,4S,5R)-3,4,5,6-tetrahydroxytetrahydro-2H-pyran-2-yl)methyl)acetamide (CAS 118377-57-4)
- DMT-2'-F-Bz-dA (CAS 136834-21-4)
- FCLA (CAS 133118-06-6)
- Salbutamol Impurity 147 (CAS 62423-71-6)
- Mirogabalin impurity 67 (CAS CATO-C4X-292467)
- Lemborexant Impurity 89 (CAS 3070371-44-4)
- 3-(4-Methylpiperazin-1-yl)propanoic acid dihydrochloride (CAS 59695-29-3)
- 4-Methyl-2-(methylthio)benzaldehyde (CAS 24852-59-3)
- 4,6-Dibromo-2-(3-fluorophenyl)-1,3-benzoxazol-5-amine (CAS 637302-87-5)
- N3-(Furan-2-ylmethyl)-1-methyl-1H-pyrazole-3,4-diamine dihydrochloride (CAS 1431963-85-7)
- Ethyl 2-(allylimino)-4-methyl-2,3-dihydrothiazole-5-carboxylate (CAS 6721-80-8)
- Methyl 4-(piperidin-4-yl)benzoate (CAS 281235-04-9)
- C-Peptide（dog） (CAS 39016-05-2)
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