Ponatinib Impurity 59 CAS CATO-C4X-226959
| CAS No. | CATO-C4X-226959 |
| Molecular Formula | C29H28ClF3N6O |
| Molecular Weight | 569.02 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Ponatinib Impurity 59 (C29H28ClF3N6O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 17.0, corresponding to approximately 17 ring(s) or double-bond equivalent(s). With a molecular weight of 569.02 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Ponatinib Impurity 59 (CAS CATO-C4X-226959) is a certified pharmaceutical impurity reference standard with the molecular formula C29H28ClF3N6O and a molecular weight of 569.02 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Ponatinib Impurity 59 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C29H28ClF3N6O |
| Molecular Weight | 569.02 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 6 |
Related Ponatinib Standards
- Ponatinib Impurity 55 (CAS CATO-C4X-226955)
- Ponatinib Impurity 29 (CAS CATO-C4X-226929)
- Ponatinib Impurity 28 (CAS CATO-C4X-226928)
- Ponatinib Impurity 10 (CAS CATO-C4X-226910)
- Ponatinib impurity 6 (CAS 2227480-51-3)
- Ponatinib Impurity 11 (CAS CATO-C4X-226911)
- Ponatinib-d8 (CAS 1562993-37-6)
- Ponatinib Impurity 14 (CAS CATO-C4X-226914)
Recommended Standards
- Formocortal (CAS 2825-60-7)
- Encorafenib Impurity 4 (CAS CATO-C4X-32494)
- Iruplinalkib (CAS 1854943-32-0)
- 3-(2,5,7-Tribromo-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid (CAS 93798-31-3)
- Sivelestat Impurity 26 (CAS 4920-92-7)
- Posaconazole Impurity 2 (CAS 2243786-00-5)
- Clopidogrel EP impurity D (CAS 1421283-60-4)
- 5-Amino-1-(4-fluoro-2-methylphenyl)-1H-pyrazole-4-carbonitrile (CAS 1159678-53-1)
- Methyl 1-(5-bromopyridin-2-yl)-5-(2-chlorophenyl)-1H-pyrazole-4-carboxylate (CAS 1150164-70-7)
- 5-(3-Chlorophenyl)-3-(3-nitrophenyl)-1,2,4-oxadiazole (CAS 690988-86-4)
- 3-O-tert-butyldimethylsilyl-4,6-o-isopropylidene-d-glucal (CAS 121846-11-5)
- Methyl 3-(Chlorosulfonyl)isonicotinate (CAS 90488-92-9)
- (4-Chloro-6-(difluoromethyl)-2-fluoropyridin-3-yl)methanol (CAS 1806914-58-8)
- TRAF6 Control Peptide trifluoroacetate salt (CAS 852690-80-3)
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