Ponatinib impurity 6 CAS 2227480-51-3
| CAS No. | 2227480-51-3 |
| Molecular Formula | C29H27F3N6O2 |
| Molecular Weight | 548.56 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ponatinib impurity 6.
CATO supplies Ponatinib impurity 6 (CAS 2227480-51-3), a pharmacopoeial impurity reference standard (molecular formula C29H27F3N6O2, MW 548.56 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C29H27F3N6O2, Ponatinib impurity 6 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 548.56 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Ponatinib impurity 6 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C29H27F3N6O2 |
| Molecular Weight | 548.56 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 6 |
Related Ponatinib Standards
- Ponatinib Impurity 10 (CAS CATO-C4X-226910)
- Ponatinib Impurity 11 (CAS CATO-C4X-226911)
- Ponatinib-d8 (CAS 1562993-37-6)
- Ponatinib (CAS 943319-70-8)
- Ponatinib Impurity 15 (E-Isomer) (CAS CATO-C4X-226915)
- Ponatinib Impurity 18 (Z-Isomer) (CAS CATO-C4X-226918)
- Ponatinib Impurity 28 (CAS CATO-C4X-226928)
- Ponatinib Impurity 43 (E-Isomer) (CAS CATO-C4X-226943)
Recommended Standards
- Apalutamide Impurity 105 (CAS CATO-C4X-2749105)
- Hydroxypioglitazone (M-VII) β-D-glucuronide, >98% (CAS 625853-75-0)
- Fmoc-Gln(Tmob)-OH (CAS 120658-64-2)
- Hydroxy Pioglitazone (M-IV) ß-D-Glucuronide (CAS 625853-76-1)
- Levodopa EP Impurity A (CAS 27244-64-0)
- Hydralazine Impurity 1 (CAS 234-80-0)
- Lamivudine Impurity 21 (CAS CATO-C4X-119421)
- Nemonoxacin Impurity 58 (CAS CATO-C4X-312858)
- (4-Amino-3-(trifluoromethyl)phenyl)dimethylphosphine oxide (CAS 2903925-23-3)
- 3-Methyl-3-(1-phenyl-1h-pyrazol-4-yl)butan-1-amine (CAS 1519241-48-5)
- N-benzyl-2-(4-methoxyphenyl)quinoline-4-carboxamide (CAS 332381-32-5)
- 3-(2-Bromo-5-fluorophenyl)acrylic acid (CAS 202865-70-1)
- [1-(Methylamino)cyclohexyl]methanol Hydrochloride (CAS 1258651-58-9)
- D-allo-Thr5-Semaglutide (CAS CATO-C4X-2226243)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com