Cyclophosphamide Impurity 44 DiHCl CAS CATO-C4X-230644

Purity ≥95%In StockPharmacopoeial Impurity Standards
CAS No.CATO-C4X-230644
Molecular FormulaC7H18ClN2O4P
Molecular WeightN/A
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Cyclophosphamide Impurity 44 DiHCl CAS CATO-C4X-230644 chemical structure

Description

The occurrence of Cyclophosphamide Impurity 44 DiHCl is closely related to an amide group, a phosphate ester group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

Cyclophosphamide Impurity 44 DiHCl (CAS CATO-C4X-230644) is a certified pharmaceutical impurity reference standard with the molecular formula C7H18ClN2O4PHCl and a molecular weight of 297.11 g/mol.

Cyclophosphamide Impurity 44 DiHCl (C7H18ClN2O4PHCl) contains an amide group, a phosphate ester group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC7H18ClN2O4P 2*HCl
Molecular Weight297.11 g/mol
Purity≥95%
StorageStore at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in methanol, ethanol, DMSO, water
StabilityLight-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)-1.5
Halogen ContentCl-containing
Nitrogen Atoms2

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