Piperaquine Impurity 1 DiHCl CAS CATO-C4X-23371
| CAS No. | CATO-C4X-23371 |
| Molecular Formula | C16H19Cl2N3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Piperaquine Impurity 1 DiHCl (CAS CATO-C4X-23371) is a certified pharmaceutical impurity reference standard with the molecular formula C16H19Cl2N3HCl and a molecular weight of 360.71 g/mol.
The molecular framework of Piperaquine Impurity 1 DiHCl (C16H19Cl2N3HCl) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Piperaquine Impurity 1 DiHCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H19Cl2N3 2*HCl |
| Molecular Weight | 360.71 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Piperaquine Standards
- Piperaquine Impurity 9 (CAS 1233345-93-1)
- Piperaquine D6 (CAS 1261394-71-1)
- Piperaquine Impurity N1 (CAS 4038-99-7)
- Piperaquine Impurity N4 (CAS 4039-00-3)
- Piperaquine Base (CAS 4085-31-8)
- Piperaquine Phosphate (CAS 85547-56-4)
- Piperaquine Tetraphosphate (CAS 911061-10-4)
- Piperaquine tetraPhosphate tetrahydrate (CAS 915967-82-7)
Recommended Standards
- Avibactam Impurity 38 (CAS 2381511-26-6)
- Ilaprazole Impurity 87 (CAS CATO-C4X-113087)
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- 1,1-Dioxo-1lambda6-thiane-2-carboxylic acid (CAS 1318758-58-5)
- Bufotenine (CAS 487-93-4)
- 5-Methyl-8-(2-(piperidin-1-yl)ethyl)-7,8-dihydro-6H-pyrrolo[3,2-e][1,2,4]triazolo[1,5-a]pyrimidine (CAS 74258-27-8)
- 1-(3-Methoxypropyl)-4-methyl-1h-pyrazol-3-amine (CAS 1344080-35-8)
- 1-(2-(4-(Trifluoromethyl)piperidin-1-yl)ethyl)imidazolidin-2-one (CAS 1191047-90-1)
- 2-(6-(4-Fluorophenyl)imidazo[2,1-b]thiazol-3-yl)-N-(o-tolyl)acetamide (CAS 897464-57-2)
- D-Leu14-Tirzepatide (CAS CATO-CPTD788920)
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