Aprepitant impurity 34 CAS CATO-C4X-237934
| CAS No. | CATO-C4X-237934 |
| Molecular Formula | C21H29NO6S2 |
| Molecular Weight | 455.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Aprepitant impurity 34 (CAS CATO-C4X-237934) is a certified pharmaceutical impurity reference standard with the molecular formula C21H29NO6S2 and a molecular weight of 455.59 g/mol.
The molecular framework of Aprepitant impurity 34 (C21H29NO6S2) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C21H29NO6S2 |
| Molecular Weight | 455.59 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 2 |
Related Aprepitant Standards
- Aprepitant impurity 53 (CAS 502537-39-5)
- Aprepitant-M3 Metabolite (CAS 419574-04-2)
- Aprepitant Impurity 23 (CAS 287930-75-0)
- Aprepitant Impurity 24 (CAS 327623-36-9)
- Aprepitant Impurity 25 (CAS CATO-C4X-114125)
- Aprepitant Impurity 26 (CAS CATO-C4X-114126)
- Aprepitant Impurity 77 (CAS CATO-C4X-114177)
- Aprepitant Impurity 78 (CAS CATO-C4X-114178)
Recommended Standards
- Ethyl 2-(2-((3-cyano-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-yl)thio)acetamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate (CAS 445383-11-9)
- Methyl 2-(bromomethyl)-6-chloro-3-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-2,3-dihydropyrimidin-1(6H)-yl)benzoate (CAS 355390-19-1)
- 6-Benzyl-2,5-dimethyl-N-(3-morpholinopropyl)-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine (CAS 862487-71-6)
- 80724-20-5 Tetramethylrhodamine isothiocyanate morpholinorhodamine isothiocyanate mritc tetramethylrhodamine 5(6)-isothiocyanate tetramethylrhodamine b isothiocyanate tetramethylrhodamine isothiocyanate isomer r tetramethylrhodamine-5-(and-6)-isothiocyanate tetramethylrhodamine-6-isothiocyanate tritc (CAS 80724-20-5)
- Tenofovir Alafenamide 64 (CAS CATO-C4X-179764)
- Ampicillin Impurity 17 (CAS CATO-C4X-144317)
- Cariprazine Impurity 53 (CAS CATO-C4X-240853)
- 3,4,5,9-Tetrahydropyrido[2,3-e]pyrrolo[1,2-a]pyrazine (CAS 155630-05-0)
- [6-(1h-imidazol-1-yl)pyridin-3-yl]methanol (CAS 111205-02-8)
- Ethyl 2-amino-5-bromo-4-(trifluoromethyl)thiophene-3-carboxylate (CAS 2137651-72-8)
- 5-(3,4-dichlorophenyl)-3-methyl-1H-1,2,4-triazole (CAS 1094730-06-9)
- 4-Ethoxy-1-fluoro-2-iodobenzene (CAS 1934682-91-3)
- n-Butane-2-d (CAS 53716-55-5)
- [pGlu] Semaglutide (CAS CATO-C4X-2226288)
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