Aprepitant Impurity 25 CAS CATO-C4X-114125
| CAS No. | CATO-C4X-114125 |
| Molecular Formula | C21H19F6NO3 |
| Molecular Weight | 447.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Aprepitant Impurity 25 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Aprepitant Impurity 25 (CAS CATO-C4X-114125, C21H19F6NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C21H19F6NO3, Aprepitant Impurity 25 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 447.37 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Aprepitant Impurity 25 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H19F6NO3 |
| Molecular Weight | 447.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Aprepitant Standards
- Aprepitant Impurity 23 (CAS 287930-75-0)
- Aprepitant Impurity 24 (CAS 327623-36-9)
- Aprepitant Impurity 26 (CAS CATO-C4X-114126)
- Aprepitant Impurity 77 (CAS CATO-C4X-114177)
- Aprepitant Impurity 78 (CAS CATO-C4X-114178)
- Aprepitant-M3 Metabolite (CAS 419574-04-2)
- Aprepitant impurity 53 (CAS 502537-39-5)
- Aprepitant impurity 34 (CAS CATO-C4X-237934)
Recommended Standards
- tert-Butyl 4-((6-bromopyridin-2-yl)(phenyl)methoxy)piperidine-1-carboxylate (CAS 2007908-37-2)
- 6-(4-(Phenyldiazenyl)phenoxy)hexyl 2-bromo-2-methylpropanoate (CAS 951322-07-9)
- Fosaprepitant Impurity 16 (CAS 327623-34-7)
- 5-Bromo-1,3-dihydro-3-[[4-(1-methylethyl)phenyl]imino]-1-(2-phenylethyl)-2H-indol-2-one (CAS 341933-43-5)
- Vitamin A EP Impurity C（Mixture of Z and E Isomers） (CAS 16729-22-9 ((3E)-Isomer))
- Doxapram Impurity 30 (CAS CATO-C4X-197330)
- Sulindac Impurity N94 (CAS CATO-CP155194)
- 5-Bromo-2-iodo-N-isopropylbenzamide (CAS 1180457-75-3)
- Ethyl 4-(2,5-dichlorophenyl)-4-oxobutanoate (CAS 898778-08-0)
- 2-(Bromomethyl)-3-methoxypyrazine (CAS 944317-85-5)
- Dec-4-en-1-ol (CAS 72255-83-5)
- 2-(4-chlorophenyl)-5-[(Z)-2-methoxy-2-phenylethenyl]furan 338786-41-7 6F-049 (CAS 338786-41-7)
- (R)-2-(2,4-difluoro-5-nitrophenyl)pyrrolidine (CAS 1212904-68-1)
- Neuropeptide Y (2-36), amide, porcine (CAS 102961-52-4)
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