Aprepitant Impurity 26 CAS CATO-C4X-114126
| CAS No. | CATO-C4X-114126 |
| Molecular Formula | C21H19F6NO3 |
| Molecular Weight | 447.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C21H19F6NO3, Aprepitant Impurity 26 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 447.37 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
CATO supplies Aprepitant Impurity 26 (CAS CATO-C4X-114126), a pharmacopoeial impurity reference standard (molecular formula C21H19F6NO3, MW 447.37 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H19F6NO3 |
| Molecular Weight | 447.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Aprepitant Standards
- Aprepitant Impurity 23 (CAS 287930-75-0)
- Aprepitant Impurity 24 (CAS 327623-36-9)
- Aprepitant Impurity 25 (CAS CATO-C4X-114125)
- Aprepitant Impurity 77 (CAS CATO-C4X-114177)
- Aprepitant Impurity 78 (CAS CATO-C4X-114178)
- Aprepitant-M3 Metabolite (CAS 419574-04-2)
- Aprepitant impurity 53 (CAS 502537-39-5)
- Aprepitant impurity 34 (CAS CATO-C4X-237934)
Recommended Standards
- Fosaprepitant Impurity 16 (CAS 327623-34-7)
- tert-Butyl 4-((6-bromopyridin-2-yl)(phenyl)methoxy)piperidine-1-carboxylate (CAS 2007908-37-2)
- Fosaprepitant Impurity 49（Racemate） (CAS CATO-C4X-116849)
- 6-(4-(Phenyldiazenyl)phenoxy)hexyl 2-bromo-2-methylpropanoate (CAS 951322-07-9)
- Eldecalcitol Impurity 8 (CAS CATO-C4X-21408)
- Fluticasone Impurity 104 (CAS CATO-C4X-1650104)
- Fudosteine Impurity 71 (CAS CATO-C4X-144771)
- Methyl 4-acetyl-2-hydroxybenzoate (CAS 27475-11-2)
- Methyl 2-[(4H-1,2,4-triazol-3-ylsulfanyl)methyl]benzoate (CAS 1547880-41-0)
- 3-((5-Bromopyrimidin-2-yl)amino)tetrahydrothiophene 1-oxide (CAS 1384672-89-2)
- 4-tert-butylpiperidin-2-one (CAS 50549-20-7)
- 2-(4-Phenyl-1H-imidazol-2-yl)benzoic acid (CAS 824395-45-1)
- Ethyl 2,4-diphenyl-5-pyrimidinecarboxylate (CAS 77995-07-4)
- Vialox Peptide(Pentapeptide-3) diacetate (CAS 725232-44-0)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com