Aprepitant Impurity 24 CAS 327623-36-9
| CAS No. | 327623-36-9 |
| Molecular Formula | C21H19F6NO3 |
| Molecular Weight | 447.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Aprepitant Impurity 24.
CATO supplies Aprepitant Impurity 24 (CAS 327623-36-9), a pharmacopoeial impurity reference standard (molecular formula C21H19F6NO3, MW 447.37 g/mol) used for the identification and quantification of trace impurities in APIs.
Aprepitant Impurity 24 (C21H19F6NO3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Aprepitant Impurity 24 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H19F6NO3 |
| Molecular Weight | 447.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Aprepitant Standards
- Aprepitant Impurity 23 (CAS 287930-75-0)
- Aprepitant Impurity 25 (CAS CATO-C4X-114125)
- Aprepitant Impurity 26 (CAS CATO-C4X-114126)
- Aprepitant Impurity 77 (CAS CATO-C4X-114177)
- Aprepitant Impurity 78 (CAS CATO-C4X-114178)
- Aprepitant-M3 Metabolite (CAS 419574-04-2)
- Aprepitant impurity 53 (CAS 502537-39-5)
- Aprepitant impurity 34 (CAS CATO-C4X-237934)
Recommended Standards
- tert-Butyl 4-((6-bromopyridin-2-yl)(phenyl)methoxy)piperidine-1-carboxylate (CAS 2007908-37-2)
- 6-(4-(Phenyldiazenyl)phenoxy)hexyl 2-bromo-2-methylpropanoate (CAS 951322-07-9)
- 5-Bromo-1,3-dihydro-3-[[4-(1-methylethyl)phenyl]imino]-1-(2-phenylethyl)-2H-indol-2-one (CAS 341933-43-5)
- 9-Bromo-7,7-diphenyl-7H-benzo[c]fluorene (CAS 1384207-26-4)
- Vonoprazan Impurity 49 (CAS CATO-C4X-1020249)
- Linagliptin Impurity 114 (CAS CATO-C4X-1101114)
- Medroxyprogesterone Impurity 16 (CAS CATO-C4X-145716)
- 5-Bromo-N,N-dimethyl-2,3-dihydro-1H-inden-2-amine (CAS 1780739-13-0)
- Brigatinib Impurity 4 (CAS CATO-C4X-26454)
- 4-(1-Hydroxyethyl)benzoic acid (CAS 97364-15-3)
- 1-(4-Fluorophenyl)-4-(3-(pyridin-4-yl)-1,2,4-oxadiazol-5-yl)-1H-1,2,3-triazol-5-amine (CAS 892766-34-6)
- 2-Deoxy-D-ribose 1,3,4-Triacetate (CAS 4258-01-9)
- 4-(3,4-Difluorobenzoyl)phenyl acetate (CAS 890100-03-5)
- Insulin Degludec Impurity 16 (CAS CATO-C4X-215716)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com