Upadacitinib Impurity 123 CAS CATO-C4X-2405123
| CAS No. | CATO-C4X-2405123 |
| Molecular Formula | C14H15NO4 |
| Molecular Weight | 261.27 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Upadacitinib Impurity 123 (CAS CATO-C4X-2405123) is a certified pharmaceutical impurity reference standard with the molecular formula C14H15NO4 and a molecular weight of 261.27 g/mol.
Upadacitinib Impurity 123 (C14H15NO4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H15NO4 |
| Molecular Weight | 261.27 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 1 |
Related Upadacitinib Standards
- Upadacitinib Impurity 11 (CAS 1708997-43-6)
- Upadacitinib Impurity 176 (CAS CATO-C4X-2405176)
- Upadacitinib Impurity 177 (CAS CATO-C4X-2405177)
- Upadacitinib Impurity 97 (CAS CATO-C4X-240597)
- Upadacitinib Impurity 49 (CAS 1944483-53-7)
- Upadacitinib Impurity 4 (CAS CATO-C4X-24054)
- Upadacitinib Impurity 187 (CAS CATO-C4X-2405187)
- Upadacitinib Impurity 48 (CAS 1869118-25-1)
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- Semaglutide Impurity 177 (CAS CATO-C4X-2226177)
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