Upadacitinib Impurity 167 CAS CATO-C4X-2405167
| CAS No. | CATO-C4X-2405167 |
| Molecular Formula | C9H13N3Si |
| Molecular Weight | 191.31 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Upadacitinib Impurity 167 (CAS CATO-C4X-2405167, C9H13N3Si) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C9H13N3Si, Upadacitinib Impurity 167 contains a nitrogen-containing heterocyclic scaffold, a nitrile group; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 191.31 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H13N3Si |
| Molecular Weight | 191.31 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 3 |
Related Upadacitinib Standards
- Upadacitinib Impurity 174 (CAS CATO-C4X-2405174)
- Upadacitinib Impurity 53 (CAS 1046861-47-5)
- Upadacitinib Impurity 166 (CAS CATO-C4X-2405166)
- Upadacitinib Impurity 46 (CAS 875781-43-4)
- Upadacitinib Impurity 67 (CAS CATO-C4X-240567)
- Upadacitinib Impurity 164 (CAS CATO-C4X-2405164)
- Upadacitinib Impurity 159 (CAS CATO-C4X-2405159)
- Upadacitinib Impurity 142 (CAS CATO-C4X-2405142)
Recommended Standards
- spiro[indene-1,4'-piperidine] (CAS 33042-66-9)
- N-(1-Ethylpropyl)-3，4-dimethylaniline (CAS 56038-89-2)
- N-Isopropyl-N-methyl-1-phenylpropan-2-amine (CAS 66514-90-7)
- N-tert-Butyl-d9-phenyl-d5-nitrone (spin trap) (CAS 119391-92-3)
- Avatrombopag Impurity 41 (CAS CATO-C4X-223441)
- Amrinone USP RC B (CAS CATO-C4X-109144)
- Anthraquinone Impurity 2 (CAS 82-21-3)
- 3-Chloro-1-isopropylisoquinoline (CAS 20922-02-5)
- Propyl dodecanoate (CAS 3681-78-5)
- Europium trioxide (CAS 1308-96-9)
- 2-[(3-Chlorophenyl)sulfanyl]-3-(4-methylphenyl)quinoline (CAS 339102-50-0)
- N-Phenylisoquinolin-5-amine (CAS 109571-87-1)
- Aripiprazole Impurity 48 (CAS 1424857-93-1)
- Galanin Message Associated Peptide (44-59) amide (CAS 125455-59-6)
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