Upadacitinib Impurity 22 CAS CATO-C4X-240522
| CAS No. | CATO-C4X-240522 |
| Molecular Formula | C17H19F3N6O |
| Molecular Weight | 380.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Upadacitinib Impurity 22 (CAS CATO-C4X-240522), a pharmacopoeial impurity reference standard (molecular formula C17H19F3N6O, MW 380.37 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Upadacitinib Impurity 22 (C17H19F3N6O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 380.37 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H19F3N6O |
| Molecular Weight | 380.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 6 |
Related Upadacitinib Standards
- Upadacitinib (CAS 1310726-60-3)
- Upadacitinib Impurity 144 (CAS CATO-C4X-2405144)
- Upadacitinib Impurity 20 (CAS CATO-C4X-240520)
- Upadacitinib Impurity 26 (CAS CATO-C4X-240526)
- Upadacitinib Impurity 28 (CAS 1310726-59-0)
- Upadacitinib-15N-d2 (CAS CATO-C4X-240579)
- Upadacitinib Impurity 128 (CAS CATO-C4X-2405128)
- Upadacitinib Impurity 72 (CAS CATO-C4X-240572)
Recommended Standards
- 2-Fluoro-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzonitrile (CAS 1029714-87-1)
- Avibactam Impurity 75 (CAS CATO-C4X-134875)
- (E)-N'-((2E,4E)-5-Phenylpenta-2,4-dien-1-ylidene)-2-(trifluoromethyl)benzenesulfonohydrazide (CAS 2765851-43-0)
- N'-[2-(4-Fluorophenoxy)ethanimidoyl]-2-phenoxypyridine-3-carbohydrazide (CAS 337928-94-6)
- Carebastine Impurity 5 (CAS CATO-C4X-31695)
- Isofluorane Impurity 5 (CAS 32778-08-8)
- Vitamin K2 Impurity 13 (CAS 587888-42-4)
- 3,5-Dibromo-4-fluorophenacyl chloride (CAS 1807057-04-0)
- 1-Benzyl-N-(2-methoxyethyl)azetidin-3-amine oxalate (CAS 1956382-06-1)
- 2-(Aminomethyl)-6-bromo-4-(difluoromethyl)-3-hydroxypyridine (CAS 1804840-76-3)
- Ethyl 4-bromo-3-ethoxybut-2-enoate (CAS 1116-50-3)
- Dimethyl D-Tartrate (CAS 5057-96-5)
- Benzyl dibenzylglycinate (CAS 141483-49-0)
- Semaglutide impurity 73 (CAS CATO-C4X-222673)
Why CATO?
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