Rimegepant Impurity 52 DiHCl CAS CATO-C4X-248752
| CAS No. | CATO-C4X-248752 |
| Molecular Formula | C16H16F2N2O |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Rimegepant Impurity 52 DiHCl (CAS CATO-C4X-248752), a pharmacopoeial impurity reference standard (molecular formula C16H16F2N2OHCl, MW 326.77 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Rimegepant Impurity 52 DiHCl (C16H16F2N2OHCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H16F2N2O 2*HCl |
| Molecular Weight | 326.77 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Rimegepant Standards
- Rimegepant Impurity 63 (CAS 1071154-76-1)
- Rimegepant Impurity 102 (CAS 1146515-11-8)
- Rimegepant Impurity 61 (CAS 1190363-43-9)
- Rimegepant Impurity 9 (CAS 1190363-46-2)
- Rimegepant Impurity 59 (CAS 1190363-47-3)
- Rimegepant Impurity 17 (CAS 1190363-50-8)
- Rimegepant (CAS 1289023-67-1)
- Rimegepant Impurity 51 (CAS 1289023-89-7)
Recommended Standards
- Ambroxol impurity 61 (CAS 104670-74-8)
- Finasteride Impurity N50 (CAS 10325-79-8)
- 【停用，见C4X-187758】Pyridoxine impurity 72 (CAS 18436-47-0（free base）)
- 3-(5-Nitropyridin-2-yl)thiazolidine (CAS 1311745-97-7)
- 4-Amino-N-cyclohexyl-1-ethyl-1h-pyrazole-3-carboxamide (CAS 895930-35-5)
- N-[(1R,2R)-2-[(11bS)-3,5-Dihydro-4H-dinaphth[2,1-c:1',2'-e]azepin-4-yl]-1,2-diphenylethyl]-4-methylbenzenesulfonamide (CAS 1034835-89-6)
- 1,4-Bis(selenocyanatomethyl)benzene (CAS 85539-83-9)
- 2,6-Difluoro-4-isopropyloxybenzaldehyde (CAS 1781138-46-2)
- 3-(5-Methyl-1,3,4-oxadiazol-2-yl)-3-phenylpropanoic acid (CAS 1082787-39-0)
- Crustacean Cardioactive Peptide (CAS 107090-96-0)
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